Division of Hematology and Medical Oncology, J. G. Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA.
J Oncol. 2009;2009:567486. doi: 10.1155/2009/567486. Epub 2009 May 6.
Epidermal growth factor receptor (EGFR) is a cell surface molecule and member of the ErbB family of receptor tyrosine kinases. Its activation leads to proliferation, antiapoptosis, and metastatic spread, making inhibition of this pathway a compelling target. In recent years, an increasing number of clinical trials in the management of solid malignancies have become available indicating the clinical efficacy of anti-EGFR monoclonal antibodies and oral small molecule tyrosine kinase inhibitors (TKIs). This review addresses frequently used EGFR inhibitors, summarizes clinical efficacy data of these new therapeutic agents, and discusses their associated toxicity and management.
表皮生长因子受体(EGFR)是细胞表面分子,也是 ErbB 家族受体酪氨酸激酶的成员。其激活可导致细胞增殖、抗细胞凋亡和转移扩散,因此抑制该通路成为一个引人注目的靶点。近年来,越来越多关于实体恶性肿瘤治疗的临床试验已经问世,表明抗 EGFR 单克隆抗体和口服小分子酪氨酸激酶抑制剂(TKIs)具有临床疗效。本文综述了常用的 EGFR 抑制剂,总结了这些新型治疗药物的临床疗效数据,并讨论了其相关毒性和管理。