Iwasaki H, Collins J G, Namiki A, Yamasawa Y, Omote K, Omote T, Matsumoto M
Department of Anesthesiology, Sapporo Medical College & Hospital.
Masui. 1991 Sep;40(9):1308-13.
The behavioral responses to tail-flick and colorectal distension after intraperitoneal administration of either small or large dose of propofol as well as of pentobarbital were studied in rats. Immediately after baseline testing, animals were randomly divided into four groups; propofol groups of 50 mg.kg-1 (n = 4) or 100 mg.kg-1 (n = 4) and pentobarbital groups of 10 mg.kg-1 (n = 4) or 20 mg.kg-1 (n = 4). Both tests were repeated every 10 minutes for 1 hour in each group. There were no changes in the thresholds of colorectal distension and tail-flick latencies in those animals receiving small doses of propofol and pentobarbital. The thresholds for colorectal distension following administration of large doses of propofol and pentobarbital had greatly increased at 10 minutes and this increase persisted for about 30 minutes although it declined gradually. In contrast, the state of high sensitivity to tail-flick test was seen in the large dose groups of both drugs. It is concluded that there are no pharmacological differences between propofol and pentobarbital in behavioral responses to somatic and visceral stimuli in rats.
研究了大鼠腹腔注射小剂量或大剂量丙泊酚以及戊巴比妥后对甩尾和结直肠扩张的行为反应。在基线测试后，动物立即被随机分为四组：丙泊酚50mg.kg-1组（n = 4）或100mg.kg-1组（n = 4）以及戊巴比妥10mg.kg-1组（n = 4）或20mg.kg-1组（n = 4）。每组每10分钟重复进行这两项测试，持续1小时。接受小剂量丙泊酚和戊巴比妥的动物，其结直肠扩张阈值和甩尾潜伏期均无变化。注射大剂量丙泊酚和戊巴比妥后，结直肠扩张阈值在10分钟时大幅升高，尽管随后逐渐下降，但这种升高持续约30分钟。相比之下，两种药物的大剂量组在甩尾测试中均表现出高敏感性状态。得出的结论是，在大鼠对躯体和内脏刺激的行为反应方面，丙泊酚和戊巴比妥之间没有药理学差异。
