Ohmori H, Iwasaki H, Omote K, Kobayashi I, Namiki A
Department of Anesthesiology, Sapporo Medical University School of Medicine.
Masui. 1994 Sep;43(9):1310-3.
We studied the differential effects of morphine and non-steroidal anti-inflammatory drug (NSAIDs) on behavioral responses to tail-flick (TF) and colorectal distension (CD) in rats. Animals were randomly divided into three groups; morphine groups (4 mg.kg-1), flurbiprofen axetil groups (30 mg.kg-1) and aspirin DL-lysin groups (100 mg.kg-1). After determining control TF and CD values, animals received each analgesic intraperitoneally, and each procedure was repeated every 10 minutes for 30 or 40 minutes. NSAIDs produced a statistically significant increase in pain threshold for CD, but not for TF. In contrast, almost similar patterns of increase in pain thresholds for CD and TF were observed in morphine groups. The present study demonstrates that NSAIDs have a powerful antinociceptive effect on visceral pain evoked by CD.
我们研究了吗啡和非甾体抗炎药（NSAIDs）对大鼠甩尾（TF）和结直肠扩张（CD）行为反应的不同影响。动物被随机分为三组；吗啡组（4mg·kg-1）、氟比洛芬酯组（30mg·kg-1）和阿司匹林赖氨酸盐组（100mg·kg-1）。在确定对照TF和CD值后，动物腹腔注射每种镇痛药，每10分钟重复进行一次每种操作，持续30或40分钟。NSAIDs使CD的痛阈有统计学意义的升高，但对TF无效。相反，在吗啡组中观察到CD和TF的痛阈升高模式几乎相似。本研究表明，NSAIDs对CD诱发的内脏痛有强大的抗伤害作用。
