Notoya A
Department of Anesthesiology, Tokyo Women's Medical College.
Masui. 1991 Sep;40(9):1387-93.
Microcirculation during excessive hemorrhage and fluid therapy under anesthesia with or without associated treatment by ulinastatin (urinary trypsin inhibitor) was studied by using the rabbit ear chamber. Sixteen rabbits were divided into 2 groups; 8 rabbits without ulinastatin treatment (C group) and rabbits treated with ulinastatin (U group). After blood withdrawal, hemodynamic disturbance appeared in both groups. But the catecholamine concentration showed no increase in either groups. Significant differences between the groups were found only in urinary output and microcirculation. These were well maintained during hemorrhage in the ulinastatin treated group. It is concluded that ulinastatin is effective in maintaining microcirculation during excessive hemorrhage and fluid therapy.
采用兔耳室研究了在麻醉状态下伴或不伴乌司他丁（尿胰蛋白酶抑制剂）联合治疗时大出血及液体疗法期间的微循环。16只兔子分为2组：8只未用乌司他丁治疗的兔子（C组）和用乌司他丁治疗的兔子（U组）。放血后，两组均出现血流动力学紊乱。但两组儿茶酚胺浓度均未升高。两组之间仅在尿量和微循环方面存在显著差异。在乌司他丁治疗组，大出血期间这些指标维持良好。得出的结论是，乌司他丁在大出血及液体疗法期间对维持微循环有效。
