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[曲坦类药物与其他偏头痛药物——二次发表]

[Triptans versus other migraine medicine--secondary publication].

作者信息

Tfelt-Hansen Peer

机构信息

Dansk Hovedpinecenter, Neurologisk Afdeling, Glostrup Hospital.

出版信息

Ugeskr Laeger. 2009 Apr 27;171(18):1485-7.

Abstract

The introduction of triptans in the treatment of migraine was apparently a revolution.Comparative randomised trials do not, however, show a clearcut picture.Oral triptans outperform oral ergotamine most because of the extremely low (< 1%) oral bioavailability of ergotamine. Compared with NSAIDs, triptants are not, in most cases, superior to aspirin. Aspirin is suggested as first-choice drug in migraine treatment. An additional advantage of aspirin is that is it much less expensive than triptans.

摘要

曲坦类药物用于偏头痛治疗显然是一场变革。然而,对比随机试验并未呈现出清晰的结果。口服曲坦类药物大多比口服麦角胺效果好,这主要是因为麦角胺的口服生物利用度极低(<1%)。与非甾体抗炎药相比,在大多数情况下,曲坦类药物并不优于阿司匹林。阿司匹林被建议作为偏头痛治疗的首选药物。阿司匹林的另一个优势是其价格比曲坦类药物便宜得多。

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