Tachibana H, Kawabata K, Takeda M, Sugita M, Kondo J, Miyauchi M, Matsuoka A
5th Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya.
Rinsho Byori. 1991 Sep;39(9):999-1004.
Short-latency somatosensory (SSEPs), brainstem auditory evoked potentials (BAEPs) and event-related potentials (ERPs) were studied in 7 patients with Binswanger's encephalopathy, 12 patients with Alzheimer's disease and 17 normal subjects. Patients with Binswanger's encephalopathy showed significantly prolonged central conduction time (CCT) and P300 latency, and prolonged tendency of I-V IPL compared to those of normal subjects. In particular, CCT showed significant prolongation compared to that of patients with Alzheimer's disease. In patients with Alzheimer's disease, I-V IPL and P300 latency were significantly prolonged compared to those of normals although there was no significant difference in CCT between Alzheimer's disease and normal subjects. These results indicate some difference between Binswanger's encephalopathy and Alzheimer's disease from the electrophysiological aspects although both of these entities are characterized by progressive mental deterioration.
对7例宾斯旺格脑病患者、12例阿尔茨海默病患者和17名正常受试者进行了短潜伏期体感诱发电位（SSEPs）、脑干听觉诱发电位（BAEPs）和事件相关电位（ERPs）研究。与正常受试者相比，宾斯旺格脑病患者的中枢传导时间（CCT）和P300潜伏期显著延长，I-V峰间潜伏期有延长趋势。特别是，与阿尔茨海默病患者相比，CCT显著延长。在阿尔茨海默病患者中，与正常人相比，I-V峰间潜伏期和P300潜伏期显著延长，尽管阿尔茨海默病患者与正常受试者之间的CCT没有显著差异。这些结果表明，尽管宾斯旺格脑病和阿尔茨海默病均以进行性精神衰退为特征，但从电生理方面来看，二者存在一些差异。
