阴道用米索前列醇与舌下含服米索前列醇用于孕中期终止妊娠及其对多普勒测量的影响
Vaginal versus sublingual misoprostol for second-trimester pregnancy termination and effect on Doppler measurements.
作者信息
Karsidag A Yasemin Karageyim, Buyukbayrak Esra E, Kars Bulent, Dansuk Ramazan, Unal Orhan, Turan M Cem
机构信息
Obstetrics Department, Dr Lutfi Kirdar Kartal Education and Research Hospital, Kartal, Istanbul, Turkey.
出版信息
Int J Gynaecol Obstet. 2009 Sep;106(3):250-3. doi: 10.1016/j.ijgo.2009.04.001. Epub 2009 May 9.
OBJECTIVE
To compare the efficacy of vaginal versus sublingual misoprostol for second-trimester pregnancy termination, and to evaluate the effect on the blood flow of the uterine and umbilical arteries.
METHODS
Forty-nine patients were randomized to receive either 200 microg of vaginal misoprostol every 6 hours or 200 microg of misoprostol sublingually every 6 hours. Doppler velocimetry studies were assessed immediately before and 60 minutes after the administration of the first dose. Standard descriptive calculations, Mann-Whitney U, Wilcoxon, and chi(2) tests were performed.
RESULTS
The mean interval between induction and onset of active labor, induction and delivery, and the duration of oxytocin administration were significantly shorter in the sublingual misoprostol group. Both routes of administration increased the Doppler indices for the uterine arteries; however, misoprostol via the sublingual route did not affect the umbilical arteries.
CONCLUSION
Sublingual administration of misoprostol for second-trimester medical abortion results in a higher success rate and does not affect umbilical blood flow.
目的
比较阴道给药与舌下含服米索前列醇用于孕中期引产的疗效，并评估其对子宫和脐动脉血流的影响。
方法
49例患者被随机分为两组，一组每6小时阴道给予200微克米索前列醇，另一组每6小时舌下含服200微克米索前列醇。在首次给药前及给药后60分钟进行多普勒测速研究。进行标准描述性计算、曼-惠特尼U检验、威尔科克森检验和卡方检验。
结果
舌下含服米索前列醇组引产至活跃产开始的平均间隔时间、引产至分娩的平均间隔时间以及缩宫素给药持续时间均显著缩短。两种给药途径均增加了子宫动脉的多普勒指数；然而，舌下给药途径对脐动脉无影响。
结论
舌下含服米索前列醇用于孕中期药物流产成功率更高，且不影响脐血流。
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