Kadota Hiroshi, Nakajima Yasoichi, Miyazaki Makoto, Sekiguchi Hirofumi, Kohno Yutaka, Kansaku Kenji
Department of Rehabilitation for Sensory Functions, Research Institute, National Rehabilitation Center for Persons with Disabilities, 4-1 Namiki, Tokorozawa, Saitama, 359-8555, Japan.
Neurosci Lett. 2009 Mar 27;453(1):1-5. doi: 10.1016/j.neulet.2009.02.005. Epub 2009 Feb 10.
Stereotyped responses must be suppressed at certain times during daily life, which can be difficult for patients with lesions in the frontal cortices. Neuropsychologists have used the rock-paper-scissors (RPS) task to evaluate patients' ability to suppress a stereotyped response. In this study, we measured functional magnetic resonance imaging signals to investigate how frontal cortex activities change corresponding to subjects' performance as they tried to lose (successfully inhibiting the typical response to win) when presented with a gesture signifying rock, paper, or scissors. Performance rates ranged from 50% to 100%, and results indicated that activation in the bilateral anterior part of the prefrontal cortex increased parametrically corresponding to subjects' successful performance. This result implies that the anterior prefrontal cortex plays a key role in the successful completion of a modified RPS task and may play a role in the suppression of stereotyped responses.
在日常生活中的某些时候，刻板反应必须被抑制，这对于额叶皮质有损伤的患者来说可能很困难。神经心理学家使用石头剪刀布（RPS）任务来评估患者抑制刻板反应的能力。在本研究中，我们测量了功能磁共振成像信号，以调查当呈现表示石头、剪刀或布的手势时，额叶皮质活动如何随着受试者试图输（成功抑制典型的赢的反应）的表现而变化。表现率从50%到100%不等，结果表明，前额叶皮质双侧前部的激活随着受试者的成功表现呈参数性增加。这一结果意味着前额叶前部皮质在成功完成改良的RPS任务中起关键作用，并且可能在抑制刻板反应中发挥作用。
