Ralchev K, Dudunkov Z, Dimitrov V, Stancheva Iu, Tsingilev D
Khirurgiia (Sofiia). 1991;44(1):53-7.
The levels of two tumor markers--CEA and CA-19.9 were repeatedly determined in 146 patients with histologically verified colo-rectal cancer and in 58 healthy controls. The normal CA-19.9 values were up to 30 U/ml. The sensitivity of the two markers proved to be low: 48.8 per cent for CEA and 37 per cent for CA-19.9. In 26 of 35 patients with local recurrence or metastases marker increase preceded the appearance of clinical symptoms of progression of the pathologic process. The two markers appeared more informative than each of them when separately determined.
对146例经组织学证实的结直肠癌患者和58例健康对照者反复测定了两种肿瘤标志物——癌胚抗原（CEA）和糖类抗原19-9（CA-19.9）的水平。CA-19.9的正常数值上限为30 U/ml。结果证明这两种标志物的敏感性较低：CEA为48.8%，CA-19.9为37%。在35例出现局部复发或转移的患者中，有26例在病理过程进展的临床症状出现之前标志物就升高了。这两种标志物联合检测时比单独检测更具信息量。
