Eskelinen M, Pasanen P, Kulju A, Janatuinen E, Miettinen P, Poikolainen E, Tarvainen R, Nuutinen P, Pääkkönen M, Alhava E
Department of Surgery, University of Kuopio, Finland.
Anticancer Res. 1994 May-Jun;14(3B):1427-32.
The aim of the present prospective study was to evaluate the clinical value ol serum tumour markers CEA, CA 50 and CA 242 in patients with colorectal cancer (n = 138) and patients with benign gastrointestinal disease (n = 104). The cutoff levels (90% specificity) determined for each test were 2.5 ng/ml for CEA, 17 U/ml for CA 50 and 17 U/ml for CA 242. The diagnostic sensitivity of the CEA test was 0.63, that of the CA 50 test was 0.30 and 0.30 for the CA 242 test in detecting colorectal cancer. CEA, CA 50 and CA 242 tests were tested in a multivariate analysis to find the best combination of independent predictors of colorectal cancer. The most important predictor of colorectal cancer was CEA followed by CA 242. In order to calculate the contributions of tumour marker tests, a diagnostic score (DS) was developed. The sensitivity of the DS in detecting colorectal cancer was 0.47 with a specificity of 0.88 and an efficiency of 0.67. On the basis of this study, serum CEA and CA 242 seem to possess diagnostic value in preoperative evaluation of patients with colorectal cancer.
本前瞻性研究的目的是评估血清肿瘤标志物癌胚抗原（CEA）、糖类抗原50（CA 50）和糖类抗原242（CA 242）在138例结直肠癌患者和104例良性胃肠道疾病患者中的临床价值。每项检测确定的临界值（特异性90%）分别为：CEA为2.5 ng/ml，CA 50为17 U/ml，CA 242为17 U/ml。CEA检测对结直肠癌的诊断敏感性为0.63，CA 50检测为0.30，CA 242检测为0.30。对CEA、CA 50和CA 242检测进行多因素分析，以找出结直肠癌独立预测指标的最佳组合。结直肠癌最重要的预测指标是CEA，其次是CA 242。为了计算肿瘤标志物检测的贡献度，制定了一个诊断评分（DS）。DS检测结直肠癌的敏感性为0.47，特异性为0.88，效率为0.67。基于本研究，血清CEA和CA 242在结直肠癌患者术前评估中似乎具有诊断价值。
