Szalmás Anita, Kónya József
Department of Medical Microbiology, Medical and Health Science Center, University of Debrecen, Nagyerdei krt. 98, Debrecen, Hungary.
Semin Cancer Biol. 2009 Jun;19(3):144-52. doi: 10.1016/j.semcancer.2009.02.011. Epub 2009 Feb 24.
During cervical carcinogenesis, the major etiologic factor, the persistent oncogenic HPV infection itself is not sufficient to immortalize and transform the epithelial host cells. Together with further genetic and epigenetic alterations disrupting the cell cycle control, the host cell acquires immortal phenotype and progresses further to an overt malignant and invasive phenotype. Here, we discuss how cancer-associated epigenetic alterations can affect the expression of papillomaviral as well as host genes in relation to stages representing the multistep process of carcinogenesis. Biomarker roles in clinical diagnosis and prognosis might be assigned to the epigenetic pattern of the involved genes.
在宫颈癌发生过程中，主要病因，即持续性致癌性人乳头瘤病毒（HPV）感染本身并不足以使上皮宿主细胞永生化并发生转化。随着进一步的遗传和表观遗传改变破坏细胞周期控制，宿主细胞获得永生化表型，并进一步发展为明显的恶性和侵袭性表型。在此，我们讨论癌症相关的表观遗传改变如何影响乳头瘤病毒基因以及宿主基因的表达，这与代表癌症发生多步骤过程的阶段相关。参与基因的表观遗传模式可能在临床诊断和预后中具有生物标志物作用。
