Amato M, Nagel R, Hüppi P
Abt. für Neonatologie, Kinderklinik, Kantonsspital, Aarau.
Klin Padiatr. 1991 Sep-Oct;203(5):389-94. doi: 10.1055/s-2007-1025460.
One hundred eight newborns (gestational age 36 + 1.8 weeks and birth weight 2860 +/- 240 g) had muscle type Creatine-Kinase activity (CK-MM) assayed immediately after birth (CK-I) and serially at 6-10 h (CK-II), 20-30 h (CK-III) and 40-60 h (CK-IV) of age. Using statistical Regression analysis, CK-MM levels were correlated to four perinatal parameters: gestational age, birth weight, neonatal acidosis (pH less than 7.15), mode of delivery (vaginal/cesarean section). It was observed that CK-MM activity was dependent on gestational age and correlated to the mode of delivery at time III (600 U/l) and IV (400 U/l) comparing the mean serum values of 156 + 44 U/l observed in atraumatic delivery (p less than or equal to 0.05). Our results demonstrate markedly higher levels of CK-MM following vaginal delivery especially if complicated by forceps, vacuum and breech presentation, suggesting that birth trauma may be responsible for this phenomenon.
108例新生儿（胎龄36 + 1.8周，出生体重2860 +/- 240 g）在出生后立即测定肌肉型肌酸激酶活性（CK-MM）（CK-I），并在出生后6 - 10小时（CK-II）、20 - 30小时（CK-III）和40 - 60小时（CK-IV）连续测定。采用统计学回归分析，CK-MM水平与四个围产期参数相关：胎龄、出生体重、新生儿酸中毒（pH小于7.15）、分娩方式（阴道分娩/剖宫产）。观察到CK-MM活性取决于胎龄，并且在III期（600 U/l）和IV期（400 U/l）时与分娩方式相关，与无创伤分娩时观察到的平均血清值156 + 44 U/l相比（p小于或等于0.05）。我们的结果表明，阴道分娩后CK-MM水平明显更高，尤其是在伴有产钳、真空吸引和臀位分娩等并发症时，提示出生创伤可能是导致这种现象的原因。
