Camps Jordi, Carrillo Oliver, Emperador Agustí, Orellana Laura, Hospital Adam, Rueda Manuel, Cicin-Sain Damjan, D'Abramo Marco, Gelpí Josep Lluís, Orozco Modesto
Joint IRB-BSC Program on Computational Biology, Institute of Research in Biomedicine, Barcelona Science Park, Josep Samitier 1-5, Barcelona, Spain.
Bioinformatics. 2009 Jul 1;25(13):1709-10. doi: 10.1093/bioinformatics/btp304. Epub 2009 May 7.
FlexServ is a web-based tool for the analysis of protein flexibility. The server incorporates powerful protocols for the coarse-grained determination of protein dynamics using different versions of Normal Mode Analysis (NMA), Brownian dynamics (BD) and Discrete Dynamics (DMD). It can also analyze user provided trajectories. The server allows a complete analysis of flexibility using a large variety of metrics, including basic geometrical analysis, B-factors, essential dynamics, stiffness analysis, collectivity measures, Lindemann's indexes, residue correlation, chain-correlations, dynamic domain determination, hinge point detections, etc. Data is presented through a web interface as plain text, 2D and 3D graphics.
FlexServ是一个基于网络的蛋白质柔性分析工具。该服务器集成了强大的协议，用于使用不同版本的正规模式分析（NMA）、布朗动力学（BD）和离散动力学（DMD）进行蛋白质动力学的粗粒度测定。它还可以分析用户提供的轨迹。该服务器允许使用多种指标对柔性进行全面分析，包括基本几何分析、B因子、主成分分析、刚度分析、集体性度量、林德曼指数、残基相关性、链相关性、动态结构域确定、铰链点检测等。数据通过网络界面以纯文本、二维和三维图形的形式呈现。
