Fisher A A, Gorban' V V, Golovina T E
Klin Med (Mosk). 1991 Jul;69(7):34-8.
Hydrogen clearance was used to assess blood flow in fundal and antral gastric mucosa as well as in the lobule of the auricle in 127 patients with ulcer (99 duodenal and 28 gastric ulcer cases), 34 patients with gastric, duodenal, pancreatic and biliary ++non-ulcer lesions against 20 healthy subjects. The findings underwent analysis in relation to the disease form and phase, baseline characteristics of the mucosa (morphological, functional and bacteriological) and changes in them in response to pentagastrin (6 micrograms/kg), alupent (0.0075 mg/kg), clofelin (0.0015 mg/kg) administration. For ulcer involving the body of the stomach and sutured perforated duodenal ulcer, fundal and antral mucosa blood flow showed a decrease by 1/3, the lowest values presenting in the active disease phase. Diminution in gastric mucosa blood flow correlated with gravity of its gastritic lesion and was not directly related to its Campylobacter contamination. Pentagastrin stimulated blood flow in fundic mucosa and led to its 30% increase whereas the flow intensity remained unaffected in the antral mucosa and skin (lobule of the auricle). Acid production in response to pentagastrin introduction rose 3.5-fold, pepsin 2.1-fold. Alupent and clofelin do not affect blood flow causing a 30-50% increase and decrease in acid and pepsin production, respectively. Separate neurohumoral regulation of gastric mucosa blood flow and secretory activity of the latter permits differential correction of each of the impaired functions.
采用氢清除法对127例溃疡患者（99例十二指肠溃疡和28例胃溃疡）、34例胃、十二指肠、胰腺和胆道非溃疡病变患者以及20名健康受试者的胃底和胃窦黏膜以及耳廓小叶的血流情况进行评估。研究结果针对疾病类型和阶段、黏膜的基线特征（形态学、功能和细菌学）以及在给予五肽胃泌素（6微克/千克）、异丙肾上腺素（0.0075毫克/千克）、氯苯乙胍（0.0015毫克/千克）后它们的变化进行了分析。对于累及胃体的溃疡和缝合的穿孔性十二指肠溃疡，胃底和胃窦黏膜血流减少了1/3，在疾病活动期出现最低值。胃黏膜血流减少与其胃炎病变的严重程度相关，与弯曲杆菌感染无直接关系。五肽胃泌素刺激胃底黏膜血流，使其增加30%，而胃窦黏膜和皮肤（耳廓小叶）的血流强度未受影响。注射五肽胃泌素后胃酸分泌增加3.5倍，胃蛋白酶分泌增加2.1倍。异丙肾上腺素和氯苯乙胍不影响血流，分别使胃酸和胃蛋白酶分泌增加30%和减少50%。胃黏膜血流和后者分泌活动的独立神经体液调节允许对每种受损功能进行差异校正。
