Wellington Hospital, Riddiford Street, Wellington, New Zealand.
Ir J Med Sci. 2011 Jun;180(2):585-6. doi: 10.1007/s11845-009-0348-y. Epub 2009 May 9.
Remitting seronegative symmetrical synovitis with pitting oedema (RS3PE syndrome) is a very rare condition incorporating a tenosynovitis of the hands and wrists, as well as the feet, ankles and shoulders. The aetiology of RS3PE syndrome is unknown, although it has been linked with infectious agents (including mycobacteria), other rheumatological conditions, HLA serotypes and malignancies.
This report examines the case of a 72-year-old man with a heart transplant and infected knee prosthesis, who developed RS3PE syndrome after introducing antibiotic treatment with rifampicin. His symptoms resolved with cessation of this agent.
This case demonstrates a possible direct aetiological link between rifampicin and RS3PE.
缓解性血清阴性对称性滑膜炎伴凹陷性水肿（RS3PE 综合征）是一种非常罕见的疾病，包括手部和腕部、足部、踝关节和肩部的腱鞘炎。RS3PE 综合征的病因尚不清楚，尽管它与感染因子（包括分枝杆菌）、其他风湿病、HLA 血清型和恶性肿瘤有关。
本报告研究了一例 72 岁男性，患有心脏移植和感染性膝关节假体，在开始使用利福平进行抗生素治疗后出现 RS3PE 综合征。停用该药物后，他的症状得到缓解。
本病例表明利福平与 RS3PE 之间可能存在直接的病因学联系。
