Van Dyke Aaron R, Jamison Timothy F
Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave, Rm 18-492, USA.
Angew Chem Int Ed Engl. 2009;48(24):4430-2. doi: 10.1002/anie.200900924.
Extension ladder: The successful application of epoxide-opening strategies towards the synthesis of ladder-type polyethers is contingent upon further elaboration of the product. By employing two different functionalized templates, a fragment of gymnocin A that bears four sites for subsequent fragment coupling has been prepared (see scheme; Bn = benzyl).
环氧开环策略在梯型聚醚合成中的成功应用取决于对产物的进一步精细构建。通过使用两种不同的功能化模板,已制备出带有四个用于后续片段偶联位点的裸甲藻毒素A片段(见方案;Bn = 苄基)。