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手性酮催化的不对称光反应。

Asymmetric photoreactions catalyzed by chiral ketones.

作者信息

Bian Bao-Ji, Yang Liu, Qiao Li-Xin, Zhang Qiang, He Wei

机构信息

Shaanxi Province Key Laboratory of Catalytic, School of Chemical and Environmental Science, Shaanxi University of Technology Hanzhong 723001 P. R. China

Department of Chemistry, School of Pharmacy, Air Force Medical University Xi'an 710032 P. R. China

出版信息

RSC Adv. 2025 Jan 30;15(4):2874-2889. doi: 10.1039/d4ra08581g. eCollection 2025 Jan 23.

DOI:10.1039/d4ra08581g
PMID:39886069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11781534/
Abstract

Asymmetric catalytic reactions are essential for synthesizing chiral drugs and fine chemicals, with their stereoselectivity influenced significantly by interactions between catalysts and substrates. Ketone catalysts have garnered considerable attention in the realm of asymmetric photoreactions because of their highly controllable structures, ease of availability, and environmental friendliness. This review highlights the application of various reported ketone catalysts in a range of asymmetric photoreactions, including [2 + 2] photocycloaddition, photoderacemization, photochemical rearrangement, asymmetric electrophilic amination, and asymmetric alkylation of aldehydes. This review discusses the design concepts, catalytic mechanisms, as well as the advantages and limitations of these catalysts within each reaction. The aim is to provide valuable insights for developing more effective asymmetric catalytic systems.

摘要

不对称催化反应对于合成手性药物和精细化学品至关重要，其立体选择性受到催化剂与底物之间相互作用的显著影响。酮催化剂因其结构高度可控、易于获得且环境友好，在不对称光反应领域备受关注。本综述重点介绍了各种已报道的酮催化剂在一系列不对称光反应中的应用，包括[2 + 2]光环加成、光消旋化、光化学重排、不对称亲电胺化以及醛的不对称烷基化。本综述讨论了这些催化剂在每个反应中的设计理念、催化机制以及优缺点。目的是为开发更有效的不对称催化体系提供有价值的见解。

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