Asymmetric photoreactions catalyzed by chiral ketones.

Asymmetric catalytic reactions are essential for synthesizing chiral drugs and fine chemicals, with their stereoselectivity influenced significantly by interactions between catalysts and substrates. Ketone catalysts have garnered considerable attention in the realm of asymmetric photoreactions because of their highly controllable structures, ease of availability, and environmental friendliness. This review highlights the application of various reported ketone catalysts in a range of asymmetric photoreactions, including [2 + 2] photocycloaddition, photoderacemization, photochemical rearrangement, asymmetric electrophilic amination, and asymmetric alkylation of aldehydes. This review discusses the design concepts, catalytic mechanisms, as well as the advantages and limitations of these catalysts within each reaction. The aim is to provide valuable insights for developing more effective asymmetric catalytic systems.