从 FGH 片段合成 Gymnocin-A 的 KLMN 片段。

Synthesis of the KLMN Fragment of Gymnocin-A from the FGH Fragment.

机构信息

Faculty of Pharmacy, Meijo University , 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan.

出版信息

J Org Chem. 2017 Apr 7;82(7):3976-3981. doi: 10.1021/acs.joc.7b00232. Epub 2017 Mar 23.

DOI:10.1021/acs.joc.7b00232

Abstract

An improved route for the synthesis of the KLMN fragment of gymnocin-A was developed through the oxiranyl anion coupling of the FGH fragment with a chiral C epoxy sulfone, followed by 6-endo cyclization. This straightforward approach reduced the number of synthetic steps by 14 compared with a previous route using alternative building blocks.

摘要

通过 FGH 片段与手性 C 环氧砜的环氧阴离子偶联，以及随后的 6-endo 环化，开发了一种改进的 Gymnocin-A 的 KLMN 片段的合成路线。与之前使用替代构建块的路线相比，这种直接的方法减少了 14 个合成步骤。