Marziniak Martin, Kienzler Claudia, Kuhlenbäumer Gregor, Sommer Claudia, Mössner Rainald
Department of Neurology, University of Münster, Münster, Germany.
J Neural Transm (Vienna). 2009 Jul;116(7):815-9. doi: 10.1007/s00702-009-0236-7. Epub 2009 May 12.
Serotonin (5-HT) plays an important role in the pathophysiology of migraine. Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in the biosynthesis of 5-HT in the brain and is therefore a major factor in the availability of 5-HT and its rate of production. We hypothesized that functional TPH2 gene variants are associated with migraine. In a case-control study approach, two proven functional and two putatively functional variants of the TPH2 gene were investigated in 266 migraine patients and 153 controls. Genotype, allele, and haplotype frequencies did not differ between healthy subjects and migraineurs. A subgroup analysis for the occurrence of aura or clinical characteristics, including the number of attacks, did not reveal a positive association for the investigated polymorphisms. Our data argue against a major influence of the TPH2 gene promoter region in migraine.
血清素（5-羟色胺，5-HT）在偏头痛的病理生理学中起重要作用。色氨酸羟化酶2（TPH2）是大脑中5-HT生物合成的限速酶，因此是5-HT可用性及其产生速率的主要因素。我们假设功能性TPH2基因变异与偏头痛有关。在一项病例对照研究中，对266例偏头痛患者和153名对照者研究了TPH2基因的两个已证实的功能性变异和两个推定的功能性变异。健康受试者和偏头痛患者之间的基因型、等位基因和单倍型频率没有差异。对先兆症状或临床特征（包括发作次数）的亚组分析未发现所研究的多态性存在正相关。我们的数据表明TPH2基因启动子区域对偏头痛没有主要影响。
