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1
First report of tirofiban-induced anemia (found in combination with severe thrombocytopenia).替罗非班诱发贫血（与严重血小板减少症并存）的首例报告。
Tex Heart Inst J. 2009;36(1):55-7.
2
Vanishing platelets: rapid and extreme tirofiban-induced thrombocytopenia after percutaneous coronary intervention for acute myocardial infarction.血小板消失：急性心肌梗死经皮冠状动脉介入治疗后替罗非班引起的快速且极度血小板减少症
Tex Heart Inst J. 2010;37(1):109-12.
3
Tirofiban-induced acute profound thrombocytopenia after primary angioplasty.原发性血管成形术后替罗非班诱发的急性严重血小板减少症。
Asian Cardiovasc Thorac Ann. 2013 Feb;21(1):74-6. doi: 10.1177/0218492312445142.
4
Tirofiban-associated acute thrombocytopenia.替罗非班相关的急性血小板减少症。
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5
Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa.使用替罗非班或依替巴肽治疗后出现的急性血小板减少症与针对配体占据的糖蛋白IIb/IIIa的特异性抗体有关。
Blood. 2002 Sep 15;100(6):2071-6.
6
Differential diagnosis and management of acute profound thrombocytopenia by tirofiban: a case report.替罗非班所致急性严重血小板减少症的鉴别诊断与处理：一例报告
J Thromb Thrombolysis. 2006 Aug;22(1):77-8. doi: 10.1007/s11239-006-7789-1.
7
Abciximab-associated thrombocytopenia after previous tirofiban-related thrombocytopenia.既往使用替罗非班相关血小板减少症后出现的阿昔单抗相关血小板减少症。
Pharmacotherapy. 2006 Mar;26(3):423-7. doi: 10.1592/phco.26.3.423.
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A case of profound and prolonged tirofiban-induced thrombocytopenia and its correction by intravenous immunoglobulin G.一例因替罗非班导致的严重且持久的血小板减少症及通过静脉注射免疫球蛋白G进行纠正的病例。
J Thromb Haemost. 2007 May;5(5):1068-70. doi: 10.1111/j.1538-7836.2007.02440.x.
9
Practical approach to the diagnosis and management of thrombocytopenia associated with tirofiban treatment.替罗非班治疗相关血小板减少症的诊断与管理实用方法
Am J Hematol. 2004 Sep;77(1):67-71. doi: 10.1002/ajh.20149.
10
Thrombocytopenia caused by abciximab or tirofiban and its association with clinical outcome in patients undergoing coronary stenting.阿昔单抗或替罗非班所致血小板减少症及其与接受冠状动脉支架置入术患者临床结局的关联
Circulation. 2004 May 11;109(18):2203-6. doi: 10.1161/01.CIR.0000127867.41621.85. Epub 2004 Apr 26.

引用本文的文献

1
Tirofiban-induced thrombocytopenia.替罗非班诱导的血小板减少症。
Ann Med. 2023 Dec;55(1):2233425. doi: 10.1080/07853890.2023.2233425.
2
An Unusual Case of Drug-Induced Thrombocytopenia.药物诱导性血小板减少症的一个不寻常案例。
J Investig Med High Impact Case Rep. 2020 Jan-Dec;8:2324709620947891. doi: 10.1177/2324709620947891.
3
A Simple Clinical Pre-procedure Risk Model for Predicting Thrombocytopenia Associated With Periprocedural Use of Tirofiban in Patients Undergoing Percutaneous Coronary Intervention.一种用于预测接受经皮冠状动脉介入治疗的患者围手术期使用替罗非班相关血小板减少症的简单临床术前风险模型。
Front Pharmacol. 2018 Dec 10;9:1456. doi: 10.3389/fphar.2018.01456. eCollection 2018.
4
Severe thrombocytopenia and alveolar hemorrhage represent two types of bleeding tendency during tirofiban treatment: case report and literature review.严重血小板减少症和肺泡出血是替罗非班治疗期间的两种出血倾向类型：病例报告和文献复习。
Int J Hematol. 2012 Sep;96(3):370-5. doi: 10.1007/s12185-012-1133-7. Epub 2012 Jul 6.

本文引用的文献

1
Frequency and management of thrombocytopenia with the glycoprotein IIb/IIIa receptor antagonists.糖蛋白IIb/IIIa受体拮抗剂所致血小板减少症的发生率及处理
Am J Cardiol. 2006 Feb 1;97(3):426-9. doi: 10.1016/j.amjcard.2005.08.066. Epub 2005 Dec 1.
2
Thrombocytopenia caused by abciximab or tirofiban and its association with clinical outcome in patients undergoing coronary stenting.阿昔单抗或替罗非班所致血小板减少症及其与接受冠状动脉支架置入术患者临床结局的关联
Circulation. 2004 May 11;109(18):2203-6. doi: 10.1161/01.CIR.0000127867.41621.85. Epub 2004 Apr 26.
3
Thrombocytopenia after treatment with platelet glycoprotein IIb/IIIa inhibitors.血小板糖蛋白IIb/IIIa抑制剂治疗后出现的血小板减少症。
Curr Hematol Rep. 2004 Mar;3(2):143-7.
4
Intravenous glycoprotein IIb/IIIa receptor antagonists reduce mortality after percutaneous coronary interventions.静脉注射糖蛋白IIb/IIIa受体拮抗剂可降低经皮冠状动脉介入治疗后的死亡率。
J Am Coll Cardiol. 2003 Jan 1;41(1):26-32. doi: 10.1016/s0735-1097(02)02666-9.
5
Acute thrombocytopenia after treatment with tirofiban or eptifibatide is associated with antibodies specific for ligand-occupied GPIIb/IIIa.使用替罗非班或依替巴肽治疗后出现的急性血小板减少症与针对配体占据的糖蛋白IIb/IIIa的特异性抗体有关。
Blood. 2002 Sep 15;100(6):2071-6.
6
Thrombocytopenia complicating treatment with intravenous glycoprotein IIb/IIIa receptor inhibitors: a pooled analysis.静脉注射糖蛋白IIb/IIIa受体抑制剂治疗并发血小板减少症：一项汇总分析。
Am Heart J. 2000 Aug;140(2):206-11. doi: 10.1067/mhj.2000.107554.
7
Clinical challenges of platelet glycoprotein IIb/IIIa receptor inhibitor therapy: bleeding, reversal, thrombocytopenia, and retreatment.血小板糖蛋白IIb/IIIa受体抑制剂治疗的临床挑战：出血、逆转、血小板减少和再治疗。
Am Heart J. 2000 Feb;139(2 Pt 2):S38-45. doi: 10.1067/mhj.2000.103742.
8
Understanding thrombocytopenia and antigenicity with glycoprotein IIb-IIIa inhibitors.了解糖蛋白IIb-IIIa抑制剂所致血小板减少症及抗原性。
Am Heart J. 1999 Oct;138(4 Pt 2):317-26. doi: 10.1053/hj.1999.v138.a100465.
9
Drug-induced immune thrombocytopenia: an overview of pathogenesis.药物性免疫性血小板减少症：发病机制概述
Semin Hematol. 1999 Jan;36(1 Suppl 1):2-6.
10
Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction.替罗非班抑制血小板糖蛋白IIb/IIIa受体在不稳定型心绞痛和非Q波心肌梗死中的应用
N Engl J Med. 1998 May 21;338(21):1488-97. doi: 10.1056/NEJM199805213382102.

替罗非班诱发贫血（与严重血小板减少症并存）的首例报告。

First report of tirofiban-induced anemia (found in combination with severe thrombocytopenia).

作者信息

Sakellariou Dimitris, Pastromas Socrates, Koulouris Spyridon, Manolis Antonis S

机构信息

1st Cardiology Department, Evagelismos Hospital, 45-47 Ypsilantou Str., Athens, Greece.

出版信息

Tex Heart Inst J. 2009;36(1):55-7.

PMID:19436788
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2676520/
Abstract

We describe the case of a 58-year-old man who developed acute severe anemia and thrombocytopenia after the administration of tirofiban following coronary artery angioplasty. The intravenous administration of IgG immunoglobulin completely resolved both the anemia and the thrombocytopenia. Although thrombocytopenia has been reported as a sequela to the use of tirofiban, there has been no prior report of a link between tirofiban use and anemia. Our successful resolution of both the anemia and the thrombocytopenia with immunoglobulin supports the theory that these severe sequelae of tirofiban are of autoimmune origin.

摘要

我们描述了一名58岁男性的病例，该患者在冠状动脉血管成形术后使用替罗非班后出现急性严重贫血和血小板减少。静脉注射免疫球蛋白G完全缓解了贫血和血小板减少。虽然血小板减少已被报道为使用替罗非班的后遗症，但此前尚无关于替罗非班使用与贫血之间关联的报道。我们使用免疫球蛋白成功缓解了贫血和血小板减少，这支持了替罗非班这些严重后遗症是自身免疫性起源的理论。