Ceballos-Viro Jaime, López-Picazo José-M, Pérez-Gracia José-L, Sola Jesús-J, Aisa Gregorio, Gil-Bazo Ignacio
Department of Oncology, Clínica Universidad de Navarra, c/Pío XII 36, 31008 Pamplona (Navarra), Spain.
World J Gastroenterol. 2009 May 14;15(18):2290-2. doi: 10.3748/wjg.15.2290.
Fibrosing cholestatic hepatitis (FCH) is a variant of viral hepatitis reported in hepatitis B virus or hepatitis C virus infected liver, renal or bone transplantation recipients and in leukemia and lymphoma patients after conventional cytotoxic chemotherapy. FCH constitutes a well-described form of fulminant hepatitis having extensive fibrosis and severe cholestasis as its most characteristic pathological findings. Here, we report a case of a 49-year-old patient diagnosed with small-cell lung cancer who developed this condition following conventional chemotherapy-induced immunosuppression. This is the first reported case in the literature of FCH after conventional chemotherapy for a solid tumor. In addition to a detailed report of the case, a physiopathological examination of this potentially life-threatening condition and its treatment options are discussed.
纤维性胆汁淤积性肝炎（FCH）是一种在乙型肝炎病毒或丙型肝炎病毒感染的肝、肾或骨移植受者以及接受传统细胞毒性化疗后的白血病和淋巴瘤患者中报道的病毒性肝炎变体。FCH是一种已被充分描述的暴发性肝炎形式，其最典型的病理表现为广泛纤维化和严重胆汁淤积。在此，我们报告一例49岁被诊断为小细胞肺癌的患者，在传统化疗诱导免疫抑制后发生了这种情况。这是文献中首次报道实体瘤传统化疗后发生FCH的病例。除了对该病例的详细报告外，还讨论了对这种可能危及生命的疾病的生理病理学检查及其治疗选择。
