Saleh Faisal, Ko Hin Hin, Davis Jennifer E, Apiratpracha Wichian, Powell James J, Erb Siegfried R, Yoshida Eric M
Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Ann Hepatol. 2007 Jul-Sep;6(3):186-9.
Fibrosing cholestatic hepatitis (FCH) is an aggressive and usually fatal form of viral hepatitis in immunocompromised patients. It is characterized by progressive cholestasis leading to hepatic failure, and a characteristic histopathological features including: periportal fibrosis, ballooning degeneration of hepatocytes, cholestasis, with minimal inflammation. FCH has been reported almost exclusively in heavily immunosuppressed organ transplant recipients or patients with AIDS. This case report describes a previously immunocompetent patient with previously stable chronic hepatitis C who developed fibrosing cholestatic hepatitis after receiving cyclophosphamide and corticosteroids for active glomerulonephritis.
纤维化淤胆型肝炎（FCH）是免疫功能低下患者中一种侵袭性且通常致命的病毒性肝炎形式。其特征为进行性胆汁淤积导致肝衰竭，以及具有特征性的组织病理学特征，包括：汇管区周围纤维化、肝细胞气球样变性、胆汁淤积，炎症轻微。FCH几乎仅在接受强效免疫抑制的器官移植受者或艾滋病患者中被报道。本病例报告描述了一名既往免疫功能正常、慢性丙型肝炎病情曾稳定的患者，在因活动性肾小球肾炎接受环磷酰胺和皮质类固醇治疗后发生了纤维化淤胆型肝炎。
