MacLellan Dawn L
Department of Urology, Dalhousie University, Halifax, Nova Scotia, Canada.
Curr Opin Urol. 2009 Jul;19(4):407-11. doi: 10.1097/MOU.0b013e32832c9178.
To review the most current literature regarding the management of neurogenic bladder in children.
Several recent papers have addressed the investigation and management of children with neurogenic bladder. Bladder wall thickness as measured by ultrasound may identify the children with urodynamic risk factors for upper urinary tract deterioration. Strategies such as maximal anticholinergic therapy, total endoscopic management, conservative management throughout puberty, and isolated bladder neck procedures to avoid bladder augmentation show promise. However, at present, there is inadequate long-term follow-up to recommend widespread application of all of these approaches. As children with neurogenic bladder enjoy longer life spans, issues including risks of malignancy related to augmentation and transition to adult-centered care will continue to gain significance.
Pediatric urologists continue to face many challenges in the management of children with neurogenic bladder. This includes identifying predictors of upper urinary tract deterioration, finding efficacious strategies to avoid bladder augmentation, and long-term care. The most recent literature attempts to address these issues. Further prospective studies with adequate follow-up will benefit our understanding of this disease process and help to choose the best strategies to achieve continence and preserve renal function in this population.
回顾有关儿童神经源性膀胱管理的最新文献。
近期有几篇论文探讨了儿童神经源性膀胱的检查与管理。超声测量的膀胱壁厚度可能有助于识别存在上尿路恶化尿动力学危险因素的儿童。诸如最大剂量抗胆碱能治疗、全内镜管理、青春期全程保守管理以及采用孤立膀胱颈手术以避免膀胱扩大等策略显示出前景。然而,目前缺乏足够的长期随访数据来推荐广泛应用所有这些方法。随着神经源性膀胱患儿的寿命延长,包括与膀胱扩大相关的恶性肿瘤风险以及向以成人为主的护理过渡等问题将继续变得重要。
小儿泌尿科医生在管理神经源性膀胱患儿方面仍面临诸多挑战。这包括识别上尿路恶化的预测因素、寻找避免膀胱扩大的有效策略以及长期护理。最新文献试图解决这些问题。进一步进行有充分随访的前瞻性研究将有助于我们理解这一疾病过程,并有助于选择最佳策略以实现该人群的控尿并保留肾功能。