Petrović Dejan, Obrenović Radmila, Stojimirović Biljana
Urology and Nephrology Clinic, Kragujevac Clinical Center, Kragujevac - Serbia.
Int J Artif Organs. 2009 Mar;32(3):173-9. doi: 10.1177/039139880903200308.
Aortic valve calcification (AVC) accelerates development of aortic valve stenosis and cardiovascular complications. Hyperphosphatemia is one of the key risk factors for aortic valve calcification.
The aim of this study was to evaluate the prevalence of AVC in patients on regular hemodialysis and to assess the impact of different factors on its appearance.
The study investigated a total of 115 patients treated in the Hemodialysis Department of the Urology and Nephrology Clinic at the Kragujevac Clinical Center in Serbia. The variables investigated were: serum albumin, C-reactive protein (CRP), homocysteine, total cholesterol, LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C), triglycerides (TG), Apolipoprotein A-I (Apo A-I), Apolipoprotein B (Apo B) and lipoprotein (a), calcium, phosphate and parathormone, and calcium-phosphorus product (Ca x P). Patients were evaluated by echocardiography for AVC. Statistical analysis included univariate and multivariate logistic regression analysis.
Univariate regression analysis showed that serum phosphate levels and Ca x P are the most important risk factors for AVC (p<0.001). Multivariate logistic regression analysis revealed that hyperphosphatemia is an independent risk factor for AVC (p<0.001).
Hyperphosphatemia is an independent risk factor for aortic valve calcification.
主动脉瓣钙化（AVC）会加速主动脉瓣狭窄和心血管并发症的发展。高磷血症是主动脉瓣钙化的关键危险因素之一。
本研究旨在评估接受定期血液透析患者的AVC患病率，并评估不同因素对其出现的影响。
该研究调查了塞尔维亚克拉古耶瓦茨临床中心泌尿外科和肾脏病诊所血液透析科治疗的115名患者。所研究的变量包括：血清白蛋白、C反应蛋白（CRP）、同型半胱氨酸、总胆固醇、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、甘油三酯（TG）、载脂蛋白A-I（Apo A-I）、载脂蛋白B（Apo B）和脂蛋白（a）、钙、磷和甲状旁腺激素，以及钙磷乘积（Ca×P）。通过超声心动图对患者进行AVC评估。统计分析包括单变量和多变量逻辑回归分析。
单变量回归分析表明，血清磷水平和Ca×P是AVC最重要的危险因素（p<0.001）。多变量逻辑回归分析显示，高磷血症是AVC的独立危险因素（p<0.001）。
高磷血症是主动脉瓣钙化的独立危险因素。
