Deshmane Satish L, Kremlev Sergey, Amini Shohreh, Sawaya Bassel E
Department of Neuroscience, Temple University School of Medicine, Philadelphia, PA 19140, USA.
J Interferon Cytokine Res. 2009 Jun;29(6):313-26. doi: 10.1089/jir.2008.0027.
Chemokines constitute a family of chemoattractant cytokines and are subdivided into four families on the basis of the number and spacing of the conserved cysteine residues in the N-terminus of the protein. Chemokines play a major role in selectively recruiting monocytes, neutrophils, and lymphocytes, as well as in inducing chemotaxis through the activation of G-protein-coupled receptors. Monocyte chemoattractant protein-1 (MCP-1/CCL2) is one of the key chemokines that regulate migration and infiltration of monocytes/macrophages. Both CCL2 and its receptor CCR2 have been demonstrated to be induced and involved in various diseases. Migration of monocytes from the blood stream across the vascular endothelium is required for routine immunological surveillance of tissues, as well as in response to inflammation. This review will discuss these biological processes and the structure and function of CCL2.
趋化因子构成一类趋化性细胞因子，根据蛋白质N端保守半胱氨酸残基的数量和间距可分为四个家族。趋化因子在选择性募集单核细胞、中性粒细胞和淋巴细胞以及通过激活G蛋白偶联受体诱导趋化作用中起主要作用。单核细胞趋化蛋白-1（MCP-1/CCL2）是调节单核细胞/巨噬细胞迁移和浸润的关键趋化因子之一。CCL2及其受体CCR2均已被证明可被诱导并参与多种疾病。单核细胞从血流穿过血管内皮的迁移对于组织的常规免疫监视以及对炎症的反应都是必需的。本综述将讨论这些生物学过程以及CCL2的结构和功能。
