Tulner Linda R, Frankfort Suzanne V, Wesselius Floor, van Campen Jos P C M, Koks Cornelis H W, Beijnen Jos H
Department of Geriatric Medicine, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands.
Curr Clin Pharmacol. 2009 May;4(2):154-8. doi: 10.2174/157488409788184990.
The most frequent intervention after Comprehensive Geriatric Assessment (CGA) is adjustment of medications. Adherence to recommendations is often incomplete. Patients at high risk of non-adherence should be identified.
To explore if changes in drug-use after CGA are carried out by the patient. To identify factors influencing non-adherence.
Co-morbidity and medication use were recorded. Patients, and when cognitively impaired, a caregiver, were questioned about advised changes. Drug-use before and after CGA was assessed. Patients were asked whether they would discontinue their drugs either with or without consulting their physician. Univariate logistic regression analysis to identify factors influencing non-adherence, was performed with SPSS.
Forty patients were included. Of the changes in medication advised, 90 % were reported to be carried out. 65 % of the patients were compliant. Only the presence of a caregiver was associated with reported complete adherence to drug therapy. Most patients can't describe for how long they will have to continue taking the drugs that are prescribed to them.
Most geriatric patients carry out changes in medication made after CGA. Supervision by caregivers may explain a high rate of reported adherence despite the presence of polypharmacy and cognitive decline.
In the absence of caregivers special attention should be paid to adherence to medication changes. Information about intended duration of drug therapy should be improved.
综合老年评估(CGA)后最常见的干预措施是调整药物治疗。对建议的依从性往往不完整。应识别出不依从风险高的患者。
探讨CGA后药物使用的变化是否由患者实施。识别影响不依从的因素。
记录合并症和药物使用情况。询问患者以及认知受损时的照料者关于建议的变化。评估CGA前后的药物使用情况。询问患者是否会在咨询或不咨询医生的情况下停药。使用SPSS进行单因素逻辑回归分析以识别影响不依从的因素。
纳入40名患者。报告称90%的药物治疗建议变化得到了实施。65%的患者依从。仅照料者的存在与报告的完全坚持药物治疗相关。大多数患者无法描述他们需要服用所开药物多长时间。
大多数老年患者实施了CGA后所做的药物治疗变化。尽管存在多种药物治疗和认知功能下降,但照料者的监督可能解释了报告的高依从率。
在没有照料者的情况下,应特别关注对药物治疗变化的依从性。应改进关于药物治疗预期持续时间的信息。