Shen Zheng, Yang Qian, You Qidong
Department of Medicinal Chemistry and Jiangsu Key Laboratory of Carcinogenesis and intervention, China Pharmaceutical University, Nanjing 210009, China.
Curr Top Med Chem. 2009;9(4):322-9. doi: 10.2174/156802609788317874.
As trans-membrane proteins located in cytoplasm and organelle membrane, potassium (K(+)) channels are generally divided into four super-families: voltage-gated K(+) channels (K(v)), Ca(2+)-activated K(+) channels (K(Ca)), inwardly rectifying K(+) channels (K(ir)) and two-pore domain K(+) channels (K(2P)). Since dysfunctions of K(+) channels would induce many diseases, various studies toward their functions in physiologic and pathologic process have been extensively launched. This review focuses on the recent advances of K(+) channels in tumor progression, including the brief introduction of K(+) channels, the role of K(+) channels in tumor cells, the possible mechanism of action at cellular level, and the possible application of K(+) channel modulators in cancer chemotherapy.
作为位于细胞质和细胞器膜中的跨膜蛋白，钾（K⁺）通道通常分为四个超家族：电压门控钾通道（Kv）、钙激活钾通道（KCa）、内向整流钾通道（Kir）和双孔域钾通道（K2P）。由于钾通道功能障碍会引发多种疾病，针对其在生理和病理过程中的功能展开了广泛的研究。本综述聚焦于钾通道在肿瘤进展方面的最新研究进展，包括钾通道的简要介绍、钾通道在肿瘤细胞中的作用、细胞水平上可能的作用机制，以及钾通道调节剂在癌症化疗中的可能应用。
