Nagano-Saito Atsuko, Liu Jiaqiang, Doyon Julien, Dagher Alain
Montreal Neurological Institute, McGill University, Quebec, Canada.
Neurosci Lett. 2009 Jul 10;458(1):1-5. doi: 10.1016/j.neulet.2009.04.025. Epub 2009 Apr 15.
Task-induced deactivation is frequently reported in the ventro-medial prefrontal cortex (vmPFC) and posterior cingulate cortex (PCC), regions considered to belong to the default mode network. To investigate the effect of dopamine on task-induced deactivation, we used positron emission tomography to measure cerebral blood flow during performance of the Tower of London task before and after administration of the dopamine receptor agonist apomorphine in six healthy volunteers (49-66 years old) and six Parkinson disease patients (52-69 years old). Although task-induced deactivation was observed in the vmPFC and PCC in both groups and in both conditions, an inverse correlation between activation and problem complexity was observed in the vmPFC only in the apomorphine condition.
任务诱导的失活经常在腹内侧前额叶皮质（vmPFC）和后扣带回皮质（PCC）中被报道，这些区域被认为属于默认模式网络。为了研究多巴胺对任务诱导失活的影响，我们使用正电子发射断层扫描来测量6名健康志愿者（49 - 66岁）和6名帕金森病患者（52 - 69岁）在给予多巴胺受体激动剂阿扑吗啡前后进行伦敦塔任务时的脑血流量。虽然在两组和两种情况下，vmPFC和PCC中均观察到任务诱导的失活，但仅在阿扑吗啡条件下，vmPFC中才观察到激活与问题复杂性之间的负相关。
