18-甲氧基冠狗牙花定阻断可卡因位置偏爱行为的获得，但增强其复现。
18-Methoxycoronaridine blocks acquisition but enhances reinstatement of a cocaine place preference.
作者信息
McCallum Sarah E, Glick Stanley D
机构信息
Albany Medical College, Albany, NY, USA.
出版信息
Neurosci Lett. 2009 Jul 17;458(2):57-9. doi: 10.1016/j.neulet.2009.04.019. Epub 2009 Apr 11.
Abstract
The iboga alkaloid congener, 18-methoxycoronaridine (18-MC), decreases self-administration of multiple drugs of abuse. Here, in a biased procedure, we investigated whether 18-MC would have a similar effect on the acquisition, expression and reinstatement of a cocaine conditioned place preference (CPP) in male Sprague-Dawley rats. While 18-MC attenuated acquisition of a cocaine CPP, it had no effect on CPP expression, and enhanced the reinstatement of cocaine CPP following extinction. Our results are consistent with those obtained using ibogaine, but reinforce the notion that acquisition, expression and reinstatement of a CPP likely involve separate mechanisms.
摘要
伊博格生物碱同系物18-甲氧基冠狗牙花定碱（18-MC）可减少多种滥用药物的自我给药行为。在此，我们采用偏向性程序，研究了18-MC对雄性Sprague-Dawley大鼠可卡因条件性位置偏爱（CPP）的获得、表达及复现是否具有类似作用。虽然18-MC减弱了可卡因CPP的获得，但对CPP的表达没有影响，并且增强了消退后可卡因CPP的复现。我们的结果与使用伊博格碱所获得的结果一致，但强化了这样一种观念，即CPP的获得、表达和复现可能涉及不同的机制。
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