University of Sydney, NSW 2006, Australia.
J Affect Disord. 2010 Jan;120(1-3):67-75. doi: 10.1016/j.jad.2009.04.011.
It has been suggested that there may be two groups of women with postnatal depression (PND) - one who have a history of depression and whose depression is etiologically similar to depression experienced at other times of life, and another who develop depression de novo in the postnatal period and whose depression is uniquely 'postnatal'. The primary aim of this study was to clarify the role of negative attitudes (general and maternal-specific) for these proposed subtypes, whilst also considering the role of a range of other potentially relevant etiological factors.
157 postnatal women were classified into four groups: (i) 'recurrent depression', (ii) 'de novo PND', (iii) 'prior (but not current) depression', (iv) 'healthy control'. Groups were compared on known vulnerability and situational risk factors for depression including negative attitudes (general and maternal-specific), personality style vulnerability, relationship insecurity, low social support, stressful life events and difficult infant behaviour. Hierarchical regressions were conducted to examine the role of general and maternal-specific negative attitudes in mediating the relationship between previous depression and PND.
Women with recurrent depression had more personality vulnerability and maternal-specific negative attitudes than women with de novo PND, but there were no differences in general negative attitudes or relationship insecurity. Non-depressed women with a history of prior depression were characterized by elevated general depression vulnerability but lower maternal-specific negative attitudes. General negative attitudes mediated the relationship between previous depression and PND.
All participants had unsettled infants and the generalizability of results to general postpartum samples is not known.
Although these results do not provide support for the proposed subtypes of PND, they highlight encouraging new avenues for cognitively based preventative interventions.
有人认为产后抑郁症(PND)可能存在两种类型——一种是有抑郁病史的患者,其抑郁与生命其他时期经历的抑郁在病因学上相似;另一种是在产后时期新出现抑郁的患者,其抑郁具有独特的“产后”特征。本研究的主要目的是阐明消极态度(一般和特定于母亲的态度)对这些提出的亚型的作用,同时考虑一系列其他潜在相关病因因素的作用。
将 157 名产后妇女分为四组:(i)“复发性抑郁症”,(ii)“产后新发抑郁症”,(iii)“既往(但非当前)抑郁症”,(iv)“健康对照组”。比较组间已知的抑郁易感性和情境风险因素,包括消极态度(一般和特定于母亲的态度)、人格风格易感性、关系不安全感、低社会支持、生活压力事件和婴儿行为困难。进行层次回归分析,以检验一般和特定于母亲的消极态度在介导既往抑郁症与 PND 之间关系中的作用。
复发性抑郁症患者的人格脆弱性和特定于母亲的消极态度比产后新发抑郁症患者更严重,但在一般消极态度或关系不安全感方面没有差异。有既往抑郁症病史但未患抑郁症的非抑郁女性表现出较高的一般抑郁易感性,但特定于母亲的消极态度较低。一般消极态度在既往抑郁与 PND 之间的关系中起中介作用。
所有参与者都有不安定的婴儿,因此结果是否适用于一般产后样本尚不清楚。
尽管这些结果不支持产后抑郁症的提出的亚型,但它们突出了基于认知的预防干预的新途径。