Tiberghien P, Chabod J, Deconinck E, Pouthier F
Etablissement Français du Sang Bourgogne-Franche-Comté, 25000 Besançon, France.
Transfus Clin Biol. 2009 May;16(2):204-8. doi: 10.1016/j.tracli.2009.03.011. Epub 2009 May 13.
A cord blood graft is now frequently used in the context of allogeneic hematopoietic transplantation. In 2007, 27% of unrelated allotransplantations performed in France used a cord blood graft. In comparison to other sources of hematopoietic grafts, cord blood has a number of advantages (immediate availability of the graft, possibility of a lesser HLA compatibility between donor and recipient...) and inconveniences (a limited number of stem cells, increased risk of infectious complications...). Recently, the possibility of combining two cord blood grafts has been demonstrated. In 2007, 55% of unrelated cord blood grafts transplantation were performed as such. Results of multicentric studies published as of now, as well as considerable potential associated with cord blood transplantation requires important efforts to increase both the quantity and quality of cord blood grafts made available for transplantation.
脐血移植物目前在异基因造血移植中经常被使用。2007年，法国进行的非亲缘异体移植中有27%使用了脐血移植物。与其他造血移植物来源相比，脐血有许多优点（移植物可立即获得、供体与受体之间HLA相容性要求较低的可能性等）和不便之处（干细胞数量有限、感染并发症风险增加等）。最近，已证明了联合两个脐血移植物的可能性。2007年，55%的非亲缘脐血移植物移植是这样进行的。截至目前发表的多中心研究结果，以及脐血移植相关的巨大潜力，都需要做出重大努力来增加可用于移植的脐血移植物的数量和质量。
