Nio Yoshinori, Iguchi Chikage, Itakura Masayuki, Toga Tomoko, Hashimoto Koji, Koike Makoto, Omori Hiroshi, Sato Yoshitoshi, Endo Shin-Ichiro
Nio Breast Surgery Clinic, Hello-Yuai Bldg. 1&2F, 511 Anenishihorikawa-cho, Nakagyo-ku, Kyoto 604-8264, Japan.
Anticancer Res. 2009 May;29(5):1607-10.
Although many reports indicated an association between thyroid diseases and breast cancer, such an association still remains controversial. The present study was aimed to clarify the association of thyroid diseases with the breast cancer incidence. In the patients with benign and malignant thyroid tumor or tumor-like disorders, the incidence of other malignancies was surveyed, and the frequency of thyroid cancer in patients with breast cancer was also surveyed.
Between 1982 and 2005, a total of 201 female patients received surgery for tumor or tumor-like disorders, including 65 carcinoma, 68 adenoma, 61 adenomatous goiter and 7 chronic thyroiditis cases. Their outcomes were surveyed in December 2006. Furthermore, during the same periods, 340 female patients underwent breast cancer surgery and their outcomes were also surveyed in December 2006.
The overall incidence rate of breast cancer was 16.4% (33/201) in the patients, who received thyroid surgeries and was much higher than other malignancies: 2.0% gastric cancer, 1.0% uterine and colorectal cancer. The incidence rate of breast cancer in each disease was 13.8% for thyroid cancer, 16.2% for adenoma and 21.3% for adenomatous goiter, but no incidence for chronic thyroiditis. On the other hand, in the patients with breast cancer during the same period in our department, the frequency of thyroid cancer was only 2.1% (7/340).
It appears that thyroid cancer, adenoma and adenomatous goiter were associated with the risk of breast cancer, but chronic thyroiditis was not related.
尽管许多报告表明甲状腺疾病与乳腺癌之间存在关联，但这种关联仍存在争议。本研究旨在阐明甲状腺疾病与乳腺癌发病率之间的关联。对患有良性和恶性甲状腺肿瘤或肿瘤样疾病的患者，调查其他恶性肿瘤的发病率，同时也调查乳腺癌患者中甲状腺癌的发生频率。
1982年至2005年间，共有201名女性患者因肿瘤或肿瘤样疾病接受手术，其中包括65例癌、68例腺瘤、61例腺瘤性甲状腺肿和7例慢性甲状腺炎病例。2006年12月对其预后进行调查。此外，在同一时期，340名女性患者接受了乳腺癌手术，并于2006年12月对其预后进行了调查。
接受甲状腺手术的患者中乳腺癌的总体发病率为16.4%（33/201），远高于其他恶性肿瘤：胃癌为2.0%，子宫癌和结直肠癌为1.0%。每种疾病中乳腺癌的发病率分别为：甲状腺癌13.8%，腺瘤16.2%，腺瘤性甲状腺肿21.3%，而慢性甲状腺炎无发病病例。另一方面，同期在我科乳腺癌患者中，甲状腺癌的发生频率仅为2.1%（7/340）。
甲状腺癌、腺瘤和腺瘤性甲状腺肿似乎与乳腺癌风险相关，而慢性甲状腺炎与之无关。
