Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, USA.
Planta Med. 2009 Oct;75(12):1326-30. doi: 10.1055/s-0029-1185687. Epub 2009 May 14.
Lipophilic fractions of stem extracts from Exocarpos latifolius, native to Papua New Guinea, showed significant activity against Mycobacterium tuberculosis H37Ra. Bioactivity-guided fractionation yielded exocarpic acid (E-octadeca-13-ene-9,11-diynoic-acid) as the major active component. Several new exocarpic acid analogs were also shown to be active. Exocarpic acid has previously been reported active against gram-positive, but not gram-negative bacteria. Work presented here demonstrates the selective activity of exocarpic acid against Mycobacterium tuberculosis H37Ra.
原产于巴布亚新几内亚的大花龙吐珠茎提取物的亲脂部分对结核分枝杆菌 H37Ra 表现出显著的活性。生物活性导向的分级分离得到的外果皮酸（E-十八碳-13-烯-9,11-二炔酸）为主要活性成分。还证明了几种新的外果皮酸类似物具有活性。外果皮酸以前被报道对革兰氏阳性菌有效，但对革兰氏阴性菌无效。这里介绍的工作表明外果皮酸对结核分枝杆菌 H37Ra 具有选择性活性。
