从大黄根中分离得到的多炔类化合物
Polyacetylenes from the Roots of King.
机构信息
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Institute of Tropical Agriculture and Forestry, Hainan University, Haikou 570228, China.
出版信息
Molecules. 2019 Apr 2;24(7):1291. doi: 10.3390/molecules24071291.
A phytochemical investigation of the roots of led to the isolation of seven polyacetylenes, including five new compounds (-) and two known ones (-). Their structures were elucidated by extensive spectroscopic analysis and detailed comparison with reported data. All the isolates were tested for their cytotoxicity against the human hepatocellular carcinoma cell line BEL-7402, human myeloid leukemia cell line K562, and human gastric carcinoma cell line SGC-7901. Compounds and showed moderate cytotoxicity against the above three human cancer cell lines with IC values ranging from 14.3 to 45.4 μM. Compound displayed cytotoxicity against the K562 and SGC-7901 cancer cell lines with IC values of 26.2 ± 0.4 and 21.9 ± 0.3 μM, respectively.
对 的根进行的植物化学研究导致分离出了七种多炔类化合物，其中包括五个新化合物（-）和两个已知化合物（-）。通过广泛的光谱分析和与报道数据的详细比较，阐明了它们的结构。所有分离物均针对人肝癌细胞系 BEL-7402、人髓系白血病细胞系 K562 和人胃癌细胞系 SGC-7901 进行了细胞毒性测试。化合物 和 对上述三种人癌细胞系具有中等细胞毒性，IC 值范围为 14.3 至 45.4 μM。化合物 对 K562 和 SGC-7901 癌细胞系的细胞毒性分别为 26.2 ± 0.4 和 21.9 ± 0.3 μM。
Zotero 插件