Davy M, Torjesen P A, Aakavaag A
Acta Endocrinol (Copenh). 1977 Jul;85(3):615-23.
Hormone production in a patient suffering from a late recurrence of a granulosa cell tumour has been studied pre- and post-operatively, and a vein on the tumour surface was cannulated at operation to collect tumour vein blood for pre-operative studies. Elevation in the plasma oestradiol level and depression in FSH and LH were found pre-operatively, and elevations were found in tumour vein oestradiol and 17alpha-hydroxyprogsterone. Plasma oestradiol level returned to normal postoperatively whereas FSH and LH levels were persistently depressed. FSH receptors were found in this tumour, and on the basis of this finding, gonadotrophins were given to athymic nude mice in an attempt to support the growth of the granulosa cell tumour implanted in these animals. We demonstrated that gonadotrophins have supported the tumour tissue, but not promoted growth.
对一名颗粒细胞瘤晚期复发患者的激素分泌情况进行了术前和术后研究，术中对肿瘤表面的一条静脉进行插管，以采集肿瘤静脉血用于术前研究。术前发现血浆雌二醇水平升高，促卵泡生成素（FSH）和促黄体生成素（LH）降低，肿瘤静脉中的雌二醇和17α-羟孕酮升高。术后血浆雌二醇水平恢复正常，而FSH和LH水平持续降低。在该肿瘤中发现了FSH受体，基于这一发现，给无胸腺裸鼠注射促性腺激素，试图支持植入这些动物体内的颗粒细胞瘤生长。我们证明促性腺激素支持了肿瘤组织，但未促进其生长。
