Cho Young Gyu, Song Hong Ji, Kim Jin Myoung, Park Kyung Hee, Paek Yu Jin, Cho Jung Jin, Caterson Ian, Kang Jun Goo
Department of Family Medicine, Seoul Paik Hospital, College of Medicine, Inje University, Seoul, Korea.
Metabolism. 2009 Jun;58(6):765-71. doi: 10.1016/j.metabol.2009.01.004.
The aim of the study was to assess cardiovascular risk in men with high body fat percentage (BF%) and normal body mass index (BMI) and men with normal BF% and high BMI. This study was a cross-sectional study using data on 5534 Korean male adults. Body mass index, BF%, and waist circumference were measured as adiposity indices. Bioelectrical impedance analysis was used for measuring BF%. Blood pressure, fasting plasma glucose, total cholesterol, triglyceride, and high-density lipoprotein cholesterol were measured routinely. Information regarding alcohol consumption, smoking, exercise, and past/current medical history was obtained by structured questionnaires. Subjects were categorized into 4 groups by means of BMI and BF% (group 1, BMI <25 kg/m(2) and BF% <25%; group 2, BMI <25 kg/m(2) and BF% > or =25%; group 3, BMI > or =25 kg/m(2) and BF% <25%; group 4, BMI > or =25 kg/m(2) and BF% > or =25%). Cardiovascular risk factors (CVRFs) such as high blood pressure, hyperglycemia, and dyslipidemia were estimated in each group. As might be expected, the prevalences of high blood pressure, hyperglycemia, and dyslipidemia were lowest in group 1 and were highest in group 4. Multivariate analyses showed that subjects in group 2 or group 4 had a 1.8 times increased risk of clustering of 2 or more CVRFs compared with subjects in group 1 (P < .001). The adjusted odds ratio (1.15; 95% confidence interval, 0.94-1.40) of subjects in group 3 on clustering of 2 or CVRFs was not significantly increased (P = .180). High BF% was related to increase of cardiovascular risk regardless of the level of BMI in Korean men. However, cardiovascular risk of men with high BMI without high BF% was not significantly increased.
本研究旨在评估高体脂百分比(BF%)且体重指数(BMI)正常的男性以及BF%正常但BMI高的男性的心血管风险。本研究为横断面研究,使用了5534名韩国成年男性的数据。测量体重指数、BF%和腰围作为肥胖指标。采用生物电阻抗分析测量BF%。常规测量血压、空腹血糖、总胆固醇、甘油三酯和高密度脂蛋白胆固醇。通过结构化问卷获取有关饮酒、吸烟、运动以及既往/当前病史的信息。根据BMI和BF%将受试者分为4组(第1组,BMI<25kg/m²且BF%<25%;第2组,BMI<25kg/m²且BF%≥25%;第3组,BMI≥25kg/m²且BF%<25%;第4组,BMI≥25kg/m²且BF%≥25%)。评估每组中的心血管危险因素(CVRF),如高血压、高血糖和血脂异常。不出所料,第1组中高血压、高血糖和血脂异常的患病率最低,第4组中最高。多变量分析显示,与第1组受试者相比,第2组或第4组受试者出现两种或更多CVRF聚集的风险增加了1.8倍(P<.001)。第3组受试者出现两种或更多CVRF聚集的校正比值比(1.15;95%置信区间,0.94 - 1.40)未显著增加(P = .180)。在韩国男性中,无论BMI水平如何,高BF%均与心血管风险增加相关。然而,BMI高但BF%不高的男性的心血管风险未显著增加。