School of Nutrition and Health Sciences, College of Nutrition, Taipei Medical University, 250 Wu-Hsing Street, Taipei, 110, Taiwan.
Department of Nutrition Science, Faculty of Medicine, Diponegoro University, Semarang, Indonesia.
Nutr J. 2018 Nov 19;17(1):106. doi: 10.1186/s12937-018-0417-z.
Metabolic syndrome is commonly associated with inflammation. The underlying factors of inflammation in metabolic syndrome are not fully understood. The objective of the study was to determine the association of dietary patterns, anthropometric measurements, and metabolic parameters with inflammatory markers in middle-aged and older adults with metabolic syndrome in Taiwan.
A total of 26,016 subjects aged ≥35 y with metabolic syndrome were recruited from Mei Jau institution between 2004 and 2013 for a cross sectional study. Metabolic syndrome was defined by the International Diabetes Federation. Multivariate logistic regression was performed to evaluate the association of dietary patterns, anthropometric measurements, and metabolic parameters with C-reactive protein (CRP) and neutrophil-to-lymphocyte ratio (NLR) in men and women with metabolic syndrome. Crude and adjusted models were analyzed by gender.
The western dietary pattern, obesity, high body fat, high waist or hip circumference, and high waist-to-hip ratio were significantly associated with increased odds ratios of high CRP and NLR in both genders. High systolic or diastolic blood pressure (BP), low high-density lipoprotein-cholesterol (HDL-C), high low-density lipoprotein-cholesterol (LDL-C), high total cholesterol (TC), high serum triglycerides (TG), and high fasting blood glucose (FBG) were significantly correlated with increased odds ratios of high CRP in both genders. Low HDL-C, high LDL-C, high serum TG, and high FBG were significantly associated with increased odds ratios of high NLR in both genders. However, high systolic (OR = 1.124, 95% CI 1.047-1.206, P < 0.01) or diastolic BP (OR = 1.176, 95% CI 1.087-1.273, P < 0.001) and high TC (OR = 1.138, 95% CI 1.062-1.220, P < 0.001) were significantly correlated with increased odds ratios of high NLR only in men.
The western dietary pattern, obese-related anthropometric parameters, and most components of metabolic syndrome are positively associated with CRP levels and NLR in men and women with metabolic syndrome.
代谢综合征通常与炎症有关。代谢综合征中炎症的潜在因素尚未完全阐明。本研究旨在确定台湾地区代谢综合征中老年患者的饮食模式、人体测量学指标和代谢参数与炎症标志物之间的关系。
本研究共纳入 2004 年至 2013 年间在 Mei Jau 机构进行的一项横断面研究中 26016 名年龄≥35 岁的代谢综合征患者。代谢综合征采用国际糖尿病联盟标准进行定义。采用多变量 logistic 回归分析评估饮食模式、人体测量学指标和代谢参数与男性和女性代谢综合征患者 C 反应蛋白（CRP）和中性粒细胞与淋巴细胞比值（NLR）之间的关系。对男女进行了未经调整和调整后的模型分析。
西方饮食模式、肥胖、体脂高、腰围或臀围高、腰臀比高与男女 CRP 和 NLR 比值升高的优势比显著相关。男女高收缩压或舒张压（BP）、低高密度脂蛋白胆固醇（HDL-C）、高低密度脂蛋白胆固醇（LDL-C）、总胆固醇（TC）、高血清甘油三酯（TG）和高空腹血糖（FBG）与 CRP 比值升高的优势比显著相关。低 HDL-C、高 LDL-C、高血清 TG 和高 FBG 与男女 NLR 比值升高的优势比显著相关。然而，高收缩压（OR=1.124，95%CI 1.047-1.206，P<0.01）或舒张压（OR=1.176，95%CI 1.087-1.273，P<0.001）和高 TC（OR=1.138，95%CI 1.062-1.220，P<0.001）与男性 NLR 比值升高的优势比显著相关。
西方饮食模式、肥胖相关人体测量学指标以及代谢综合征的大多数成分与男性和女性代谢综合征患者的 CRP 水平和 NLR 呈正相关。
