Department of Medicine, Division of Cardiology, SUNY Downstate Medical Center, Brooklyn, NY 11203-2098, United States.
Atherosclerosis. 2009 Nov;207(1):261-5. doi: 10.1016/j.atherosclerosis.2009.04.011. Epub 2009 Apr 17.
Phospholipid transfer protein (PLTP) is an important modulator of phospholipid transfer and exchange among proteins. It also plays a role in inflammation and oxidative stress. Accordingly, PLTP has been implicated in the development of atherosclerosis. Left ventricular (LV) systolic dysfunction is common in patients with atherosclerosis, and both inflammation and oxidative stress have also been implicated in its development and progression. The goal of the present study was to examine the relation between plasma PLTP activity and LV systolic function. Baseline plasma PLTP activity was measured in 389 male patients referred for coronary angiography for a variety of indications. Detailed clinical, angiographic and laboratory characteristics were available for the patients. Compared to those patients with normal LV function (defined as an ejection fraction of >or=55% on ventriculography), patients with any degree of LV dysfunction had elevated PLTP activity (median PLTP 17.8 pmol/microl/h versus 15.9 pmol/microl/h, p=0.0038). Using multivariate analysis, and adjusting for a variety of confounding variables known to affect both LV function and PLTP activity, PLTP activity was an independent predictor of the presence of any left ventricular systolic dysfunction in the entire population (OR 1.47, 95% CI 1.12-1.93, p=0.0052). Furthermore, PLTP activity was an independent predictor of the presence of LV dysfunction in both patients with and without myocardial infarction on presentation (OR 2.39, 95% CI 1.18-4.86, p=0.0161 and OR 1.41, 95% CI 1.05-1.89, p=0.0206, respectively). In conclusion, PLTP activity may represent a novel marker of LV systolic dysfunction in patients with known or suspected coronary artery disease.
磷脂转运蛋白（PLTP）是一种重要的磷脂转运和蛋白间交换的调节剂。它还在炎症和氧化应激中发挥作用。因此，PLTP 与动脉粥样硬化的发展有关。左心室（LV）收缩功能障碍在动脉粥样硬化患者中很常见，炎症和氧化应激也与它的发展和进展有关。本研究的目的是研究血浆 PLTP 活性与 LV 收缩功能之间的关系。在 389 名因各种原因接受冠状动脉造影的男性患者中，测量了基线血浆 PLTP 活性。患者的详细临床、血管造影和实验室特征都可获得。与那些左心室功能正常的患者（定义为心室造影时射血分数>或=55%）相比，任何程度的 LV 功能障碍患者的 PLTP 活性升高（中位数 PLTP 为 17.8 pmol/微升/小时与 15.9 pmol/微升/小时，p=0.0038）。使用多元分析，并调整了已知影响 LV 功能和 PLTP 活性的多种混杂变量，PLTP 活性是整个人群中存在任何左心室收缩功能障碍的独立预测因子（OR 1.47，95%CI 1.12-1.93，p=0.0052）。此外，PLTP 活性是有或没有心肌梗死患者存在 LV 功能障碍的独立预测因子（OR 2.39，95%CI 1.18-4.86，p=0.0161 和 OR 1.41，95%CI 1.05-1.89，p=0.0206）。总之，PLTP 活性可能是已知或疑似冠状动脉疾病患者 LV 收缩功能障碍的一个新的标志物。
