De Vries Jolanda, Van der Steeg Alida F, Roukema Jan A
Department of Medical Psychology, CoRPS, Tilburg University, PO Box 90153, 5000 LE Tilburg, The Netherlands.
J Psychosom Res. 2009 Jun;66(6):495-502. doi: 10.1016/j.jpsychores.2008.11.008. Epub 2009 Jan 20.
The objective of this study was to examine the predictors of fatigue 6 and 12 months after surgical treatment in women with early-stage breast cancer (BC group) and in women with benign breast problems (BBP group) in a prospective follow-up study.
Women entered the study prior to diagnosis and completed questionnaires on personality factors, psychological factors, and social support. Fatigue was assessed 6 and 12 months after diagnosis (BBP group) or surgical treatment (BC group). Clinical data were taken from medical records.
In the BC group (n=117), fatigue at 6 months was predicted by trait anxiety (P<.001) and extraversion (P<.05). Trait anxiety (P<.05), extraversion (P<.05), and depressive symptoms (P<.05) predicted fatigue at 12 months. In the BBP group (n=190), the predictors were trait anxiety (P<.001) for fatigue at 6 months, and trait anxiety (P<.001) and neuroticism (P<.01) for fatigue at 12 months.
Many patients who are already fatigued before diagnosis remain tired regardless of diagnosis. Trait anxiety is strongly related to fatigue in both groups.
本前瞻性随访研究旨在探究早期乳腺癌女性患者（BC组）和乳腺良性疾病女性患者（BBP组）手术治疗后6个月和12个月疲劳的预测因素。
女性在确诊前进入研究，并完成关于人格因素、心理因素和社会支持的问卷调查。在确诊后6个月和12个月（BBP组）或手术治疗后6个月和12个月（BC组）评估疲劳情况。临床数据取自病历。
在BC组（n = 117）中，6个月时的疲劳由特质焦虑（P <.001）和外向性（P <.05）预测。特质焦虑（P <.05）、外向性（P <.05）和抑郁症状（P <.05）预测12个月时的疲劳。在BBP组（n = 190）中，6个月时疲劳的预测因素是特质焦虑（P <.001），12个月时疲劳的预测因素是特质焦虑（P <.001）和神经质（P <.01）。
许多在诊断前就已疲劳的患者，无论诊断结果如何，仍然感到疲倦。特质焦虑在两组中都与疲劳密切相关。
