Lockefeer J P M, De Vries J
Department of Medical Psychology, TweeSteden Hospital, Tilburg, The Netherlands.
Psychooncology. 2013 May;22(5):1127-33. doi: 10.1002/pon.3115. Epub 2012 Jun 13.
Depressive symptoms, fatigue, and low sleep quality are common symptoms during and after breast cancer (BC) treatment. In the present study, the relationship between trait anxiety and these symptoms in a long follow-up period was examined.
This was a prospective study. Participants, composed of 163 women with BC and 224 women with benign breast problems (BBPs), completed questionnaires on depressive symptoms, fatigue, and sleep quality before diagnosis and 1, 3, 6, 12, and 24 months after diagnosis (BBP group) or surgical treatment (BC group). In addition, patients completed a questionnaire on trait anxiety before diagnosis.
Trait anxiety was the most significant predictor for depressive symptoms (p < 0.001) and lower sleep quality (p = 0.040) at 2-year follow-up. For fatigue, fatigue at baseline and trait anxiety together was the most important predictor (p < 0.001). Linear mixed model analyses showed that there was an interaction effect of time with trait anxiety and with diagnosis for depressive symptoms (p = 0.001 and p < 0.001) and fatigue (p = 0.004 and p < 0.001). There was no interaction effect of time with trait anxiety or diagnosis for sleep quality (p = 0.055 and p = 0.225). Together with diagnosis, trait anxiety was an important determinant of depressive symptoms, fatigue, and low sleep quality following diagnosis of BBP or BC and seemed to be a common factor in these persisting symptoms.
抑郁症状、疲劳和低睡眠质量是乳腺癌（BC）治疗期间及之后的常见症状。在本研究中，我们考察了特质焦虑与这些症状在长期随访期间的关系。
这是一项前瞻性研究。参与者包括163名乳腺癌女性患者和224名患有良性乳腺疾病（BBP）的女性，她们在诊断前以及诊断后1、3、6、12和24个月（BBP组）或手术治疗后（BC组）完成了关于抑郁症状、疲劳和睡眠质量的问卷调查。此外，患者在诊断前还完成了一份关于特质焦虑的问卷。
在2年随访中，特质焦虑是抑郁症状（p < 0.001）和较低睡眠质量（p = 0.040）的最显著预测因素。对于疲劳，基线时的疲劳和特质焦虑共同是最重要的预测因素（p < 0.001）。线性混合模型分析表明，时间与特质焦虑以及与抑郁症状的诊断之间存在交互作用（p = 0.001和p < 0.001），与疲劳也存在交互作用（p = 0.004和p < 0.001）。时间与特质焦虑或睡眠质量诊断之间不存在交互作用（p = 0.055和p = 0.225）。与诊断一起，特质焦虑是BBP或BC诊断后抑郁症状、疲劳和低睡眠质量的重要决定因素，并且似乎是这些持续症状的一个共同因素。
