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慢性粒细胞白血病表现为双表型原始细胞危象，随后谱系转换为B淋巴细胞白血病。

Chronic myelogenous leukemia showing biphenotypic blast crisis followed by lineage switch to B lymphoblastic leukemia.

作者信息

Oh Seung Hwan, Park Tae Sung, Kim Hye Ran, Lee Ja Young, Kim Jae Hyun, Shin Jeong Hwan, Lee Jeong Nyeo

出版信息

Leuk Res. 2009 Nov;33(11):e195-8. doi: 10.1016/j.leukres.2009.04.026. Epub 2009 May 17.

DOI:10.1016/j.leukres.2009.04.026
PMID:19446879
Abstract

Lineage switch is a very rare event in blastic crisis of chronic myelogenous leukemia (CML-BC). To our knowledge, only three cases of lineage switch between lymphoid and myeloid/myelomonocytic lineages have been reported in the literature. Here, we report a novel case of imatinib-resistant CML-BC, in which the blast lineage switched from biphenotypic to B-lymphoid.

摘要

谱系转换在慢性粒细胞白血病急变期（CML-BC）中是非常罕见的事件。据我们所知，文献中仅报道了3例淋巴系与髓系/粒单核系之间的谱系转换。在此，我们报告1例伊马替尼耐药的CML-BC新病例，其中原始细胞谱系从双表型转换为B淋巴细胞系。

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