Calderón-Cabrera C, Montero I, Morales R M, Sánchez J, Carrillo E, Caballero-Velázquez T, Prats C, Bernal R, De Blas J M, Pérez-Simón J A
UGC Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Instituto de Biomedicina de Sevilla (IBIS)/CSIC/Universidad de Sevilla, Sevilla, Spain.
UGC Genética, Reproducción y Medicina Fetal. Hospital Universitario Virgen del Rocío.
Leuk Res Rep. 2013 Sep 21;2(2):79-81. doi: 10.1016/j.lrr.2013.08.001. eCollection 2013.
Frequency of additional chromosomal abnormalities in chronic myeloid leukemia (CML) is estimated to be 7% in chronic phase and increases to 40-70% in advanced disease. Progression of CML from chronic phase to accelerated phase or blast crisis is often associated with secondary chromosomal aberrations. We report an exceptional case of CML as debut in lymphoblastic blast crisis and a subsequent progression in myeloblastic blast crisis with rare cytogenetic abnormalities.
慢性髓性白血病（CML）中额外染色体异常的发生率在慢性期估计为7%，在疾病进展期则升至40%-70%。CML从慢性期进展为加速期或急变期通常与继发性染色体畸变有关。我们报告了1例罕见的首次表现为淋巴细胞母细胞急变期的CML病例，随后进展为粒细胞母细胞急变期，并伴有罕见的细胞遗传学异常。
