Martig Adria K, Jones Graham L, Smith Kelsey E, Mizumori Sheri J Y
Psychology Department, Box 351525, University of Washington, Seattle, WA 98195-1525, United States.
Behav Brain Res. 2009 Nov 5;203(2):316-20. doi: 10.1016/j.bbr.2009.05.008. Epub 2009 May 15.
Rats were tested on a hippocampus dependent win-shift working memory task in familiar or novel environments after receiving bilateral ventral tegmental area infusions of baclofen. Baclofen infusion disrupted working memory performance in both familiar and novel environments. In addition, baclofen infusion selectively disrupted short-term working memory in the novel environment. This experiment confirms selective ventral tegmental area support of accurate performance during a context dependent spatial navigation task.
在双侧腹侧被盖区注入巴氯芬后，对大鼠在熟悉或新奇环境中进行依赖海马体的赢-转换工作记忆任务测试。注入巴氯芬会破坏熟悉和新奇环境中的工作记忆表现。此外，注入巴氯芬会在新奇环境中选择性地破坏短期工作记忆。该实验证实了腹侧被盖区在依赖情境的空间导航任务中对准确表现的选择性支持。
