Gill Kathryn M, Mizumori Sheri J Y
Department of Psychology, University of Washington, Seattle, WA 98195, USA.
Behav Neurosci. 2006 Apr;120(2):377-92. doi: 10.1037/0735-7044.120.2.377.
Place-specific firing by hippocampal and striatal neurons was recorded simultaneously following injection of a D(1) receptor antagonist (SCH23390) and during spatial working memory task performance. SCH23390-induced changes in unit responses were observed during light and dark test conditions. Although hippocampal place field locations were altered by the contextual change, the reliability and specificity of place fields was disrupted only by combining D(1) antagonism and a change in context. Striatal place field locations were reorganized after either contextual change or D(1) antagonism, without altering place field reliability and specificity. Disrupted velocity encoding by place cells in both regions was induced by darkness, whereas greater stability in acceleration encoding followed removal of D(1) receptor activity. Dopamine may differentially regulate hippocampal context learning and striatum-based predictive codes.
在注射D(1)受体拮抗剂（SCH23390）后以及空间工作记忆任务执行期间，同时记录了海马体和纹状体神经元的位置特异性放电。在明、暗测试条件下观察到SCH23390诱导的单位反应变化。尽管海马体位置场的位置因环境变化而改变，但只有将D(1)拮抗作用与环境变化相结合，位置场的可靠性和特异性才会受到破坏。在环境变化或D(1)拮抗作用后，纹状体位置场的位置会重新组织，而不会改变位置场的可靠性和特异性。黑暗会诱导两个区域的位置细胞对速度的编码受到破坏，而去除D(1)受体活性后，加速度编码的稳定性更高。多巴胺可能对海马体的环境学习和基于纹状体的预测编码有不同的调节作用。
