MCH 功能的动物模型及其在能量平衡中的作用。
Animals models of MCH function and what they can tell us about its role in energy balance.
机构信息
Beth Israel Deaconess Medical Center, Boston, MA 02446, United States.
出版信息
Peptides. 2009 Nov;30(11):2040-4. doi: 10.1016/j.peptides.2009.05.002. Epub 2009 May 15.
Abstract
Melanin-concentrating hormone (MCH) has attracted considerable attention because of its effects on food intake and body weight and the MCH receptor (MCHR1) remains one of the viable targets for obesity therapy. This review summarizes the literature examining the effects of MCH on body weight, food intake and energy expenditure in rodent models, and the central sites where MCH acts in regulating energy homeostasis. Emphasis is given on the discrepancies between the genetic and pharmacologic models of MCHR1 inactivation. We propose some solutions to resolve these discrepancies and discuss some future directions in MCH research.
摘要
黑色素浓缩激素 (MCH) 因其对食物摄入和体重的影响而引起了相当大的关注，并且 MCH 受体 (MCHR1) 仍然是肥胖症治疗的可行靶标之一。本综述总结了检查 MCH 在啮齿动物模型中对体重、食物摄入和能量消耗的影响的文献，以及 MCH 在调节能量平衡中起作用的中枢部位。重点介绍了 MCHR1 失活的遗传和药理学模型之间的差异。我们提出了一些解决这些差异的方法，并讨论了 MCH 研究的一些未来方向。
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本文引用的文献
1
Effects of intracerebroventricular and intra-accumbens melanin-concentrating hormone agonism on food intake and energy expenditure.脑室内和伏隔核内注射黑色素聚集激素激动剂对食物摄入和能量消耗的影响。
Am J Physiol Regul Integr Comp Physiol. 2009 Mar;296(3):R469-75. doi: 10.1152/ajpregu.90556.2008. Epub 2009 Jan 7.
2
Dysregulation of the mesolimbic dopamine system and reward in MCH-/- mice.中脑边缘多巴胺系统失调与MCH基因敲除小鼠的奖赏行为
Biol Psychiatry. 2008 Aug 1;64(3):184-91. doi: 10.1016/j.biopsych.2007.12.011. Epub 2008 Feb 20.
3
The melanin-concentrating hormone system and its physiological functions.黑色素聚集激素系统及其生理功能。
Results Probl Cell Differ. 2008;46:159-79. doi: 10.1007/400_2007_052.
4
Behavioral and biochemical responses to d-amphetamine in MCH1 receptor knockout mice.MCH1受体基因敲除小鼠对d-苯丙胺的行为和生化反应。
Synapse. 2008 Feb;62(2):128-36. doi: 10.1002/syn.20473.
5
Microinjections of melanin concentrating hormone into the nucleus tractus solitarius of the rat elicit depressor and bradycardic responses.向大鼠孤束核微量注射黑色素聚集激素可引发降压和心动过缓反应。
Neuroscience. 2007 Dec 19;150(4):796-806. doi: 10.1016/j.neuroscience.2007.10.002. Epub 2007 Oct 5.
6
Peptide ligands for the melanin-concentrating hormone (MCH) receptor 1.黑色素聚集激素（MCH）受体1的肽配体。
Curr Top Med Chem. 2007;7(15):1425-32. doi: 10.2174/156802607782194734.
7
Anti-obesity effects of small molecule melanin-concentrating hormone receptor 1 (MCHR1) antagonists.小分子促黑素细胞激素受体1（MCHR1）拮抗剂的抗肥胖作用
Life Sci. 2007 Jul 19;81(6):423-40. doi: 10.1016/j.lfs.2007.05.029. Epub 2007 Jun 27.
8
Melanin concentrating hormone is a novel regulator of islet function and growth.黑色素聚集激素是胰岛功能和生长的新型调节因子。
Diabetes. 2007 Feb;56(2):311-9. doi: 10.2337/db06-0708.
9
Potent, selective, and orally efficacious antagonists of melanin-concentrating hormone receptor 1.强效、选择性且口服有效的促黑素细胞激素受体1拮抗剂。
J Med Chem. 2006 Nov 30;49(24):7095-107. doi: 10.1021/jm060572f.
10
Optimization of chromone-2-carboxamide melanin concentrating hormone receptor 1 antagonists: assessment of potency, efficacy, and cardiovascular safety.色酮-2-甲酰胺类黑色素浓缩激素受体1拮抗剂的优化：效能、疗效及心血管安全性评估
J Med Chem. 2006 Nov 2;49(22):6569-84. doi: 10.1021/jm060683e.
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