Center for Infectious Disease Research and Biosafety Laboratories, Department of Microbiology and Cell Biology, Indian Institute of Science, Bangalore 560012, India.
Int J Biochem Cell Biol. 2009 Nov;41(11):2129-33. doi: 10.1016/j.biocel.2009.05.006. Epub 2009 May 15.
The LysR-type transcriptional regulators (LTTRs) are widely distributed in various genera of prokaryotes. LTTRs are DNA binding proteins that can positively or negatively regulate target gene expression and can also repress their own transcription. Salmonella enterica comprises a group of Gram-negative bacteria capable of causing clinical syndromes that range from self-limiting diarrhoea to severe fibrinopurulent necrotizing enteritis and life threatening systemic disease. The survival and replication of Salmonella in macrophages and in infected host is brought about by the means of various two component regulatory systems, transporters and other virulence islands. In Salmonella genome the existence of 44 LTTRs has been documented. These LTTRs regulate bacterial stress response, systemic virulence in mice and also many virulence determinants in vitro. Here we focus on the findings that elucidate the structure and function of the LTTRs in Salmonella and discuss the importance of these LTTRs in making Salmonella a successful pathogen.
LysR 型转录调节因子（LTTRs）广泛分布于各种原核生物的属中。LTTRs 是 DNA 结合蛋白，可正向或负向调节靶基因表达，还可抑制自身转录。肠道沙门氏菌由一组革兰氏阴性细菌组成，能够引起从自限性腹泻到严重的纤维素性化脓性坏死性肠炎和危及生命的全身性疾病等多种临床综合征。沙门氏菌在巨噬细胞和感染宿主中的存活和复制是通过各种双组分调控系统、转运蛋白和其他毒力岛来实现的。在沙门氏菌基因组中已经记录到存在 44 个 LTTRs。这些 LTTRs 调节细菌的应激反应、在小鼠中的系统毒力以及许多体外毒力决定因素。在这里，我们重点介绍阐明沙门氏菌 LTTRs 的结构和功能的发现，并讨论这些 LTTRs 在使沙门氏菌成为成功病原体方面的重要性。
