Institut de Bioenginyeria de Catalunya, Barcelona, Spain.
FEMS Microbiol Lett. 2011 Feb;315(1):63-71. doi: 10.1111/j.1574-6968.2010.02171.x. Epub 2010 Dec 22.
A genetic screening for osmoregulated genes allowed us to identify the yfeR gene of Salmonella enterica serovar Typhimurium. The yfeR gene product encodes a novel LysR-type transcriptional regulator (LTTR), the expression of which decreases when external osmolarity increases. Out of the adjacent gene yfeH, YfeR modulates expression of several genes that may be required for optimal growth under low osmolarity conditions.
遗传筛选渗透压调节基因使我们能够鉴定出肠炎沙门氏菌 Typhimurium 的 yfeR 基因。yfeR 基因产物编码一种新型的 LysR 型转录调节因子（LTTR），当外部渗透压增加时，其表达减少。在相邻的 yfeH 基因之外，YfeR 调节几个基因的表达，这些基因可能是在低渗透压条件下最佳生长所必需的。
