Nyst Heike J, Tan I Bing, Stewart Fiona A, Balm Alfons J M
Department of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Photodiagnosis Photodyn Ther. 2009 Mar;6(1):3-11. doi: 10.1016/j.pdpdt.2009.03.002. Epub 2009 May 5.
The mainstay treatments for head and neck carcinomas are surgery, radiotherapy and chemotherapy. These treatment options may be associated with considerable complications. Radical radiotherapy and chemotherapy can generally be employed only once, which presents difficulties in cases of recurrent disease or second primaries within the irradiated field. Salvage surgery at the same site is often difficult, due to progressive tissue loss. In this respect photodynamic therapy (PDT) seems to be a good alternative treatment option for small, localized tumors; with a good outcome and with excellent functional and cosmetic results. Selected patients with advanced cancer of the head and neck, who have exhausted other treatment options, can also achieve improvement in quality of life with PDT. The advantages of PDT compared with surgery or radiotherapy are reduced long-term morbidity and the fact that PDT does not compromise future treatment options for recurrent, residual or second primary disease.
头颈部癌的主要治疗方法是手术、放疗和化疗。这些治疗选择可能会伴有相当多的并发症。根治性放疗和化疗通常只能进行一次，这给照射野内复发性疾病或第二原发肿瘤的治疗带来了困难。由于组织的渐进性缺失，在同一部位进行挽救性手术往往很困难。在这方面，光动力疗法（PDT）似乎是小的局限性肿瘤的一种很好的替代治疗选择；其疗效良好，功能和美容效果极佳。对于那些已用尽其他治疗选择的晚期头颈部癌患者，PDT也可以改善其生活质量。与手术或放疗相比，PDT的优势在于长期发病率较低，且PDT不会影响复发性、残留性或第二原发性疾病未来的治疗选择。
