缺氧缺血后P2X4R在未成熟大鼠脑中的延迟表达与小胶质细胞有关。
Delayed P2X4R expression after hypoxia-ischemia is associated with microglia in the immature rat brain.
作者信息
Wixey Julie A, Reinebrant Hanna E, Carty Michelle L, Buller Kathryn M
机构信息
Perinatal Research, Clinical Neuroscience, University of Queensland Centre for Clinical Research, Herston, Queensland 4029, Australia.
出版信息
J Neuroimmunol. 2009 Jul 25;212(1-2):35-43. doi: 10.1016/j.jneuroim.2009.04.016. Epub 2009 May 17.
In a preterm hypoxia-ischemia model in the post-natal day 3 rat, we characterized how the expression of purine ionotropic P2X(4) receptors change in the brain post-insult. After hypoxia-ischemia, P2X(4) receptor expression increased significantly and was associated with a late increase in ionised calcium binding adapter molecule-1 protein expression indicative of microglia cell activation. Minocycline, a potent inhibitor of microglia, attenuated the hypoxia-ischemia-induced increase in P2X(4) receptor expression. We postulate that P2X(4) receptor-positive microglia may represent a population of secondary injury-induced activated microglia. Future studies will determine whether this population contributes to the progression of injury in the immature brain.
在出生后第3天大鼠的早产缺氧缺血模型中，我们研究了嘌呤离子型P2X(4)受体在脑损伤后的表达变化。缺氧缺血后，P2X(4)受体表达显著增加，并与离子钙结合衔接分子-1蛋白表达的后期增加相关，提示小胶质细胞活化。米诺环素是一种有效的小胶质细胞抑制剂，可减轻缺氧缺血诱导的P2X(4)受体表达增加。我们推测，P2X(4)受体阳性小胶质细胞可能代表继发性损伤诱导的活化小胶质细胞群体。未来的研究将确定该群体是否会导致未成熟脑损伤的进展。
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