National Drug and Alcohol Research Centre, University of New South Wales, Sydney NSW 2052, Australia.
Addict Behav. 2009 Sep;34(9):723-9. doi: 10.1016/j.addbeh.2009.04.011. Epub 2009 May 3.
This paper aimed to determine whether non-fatal opioid overdose and suicide attempts are distinct behaviours by examining the histories of 1500 opioid-dependent individuals. This paper utilised data collected as part of a large retrospective case-control study. Unintentional non-fatal opioid overdoses were more common than suicide attempts (58% vs. 32%). Overall, the correlates associated with a history of attempted suicide only and non-fatal opioid overdose only were different. Drug-related risk behaviours (including high impulsivity, injection of opioids, sedative dependence) were associated with non-fatal opioid overdose; and a history of mental disorders (depression, anxiety disorder, and screening positive for borderline personality disorder (BPD+) were associated with suicide attempts. Additionally, those who reported a history of both behaviours had a more severe clinical profile including excessive drug use, psychological disorders and childhood trauma. The study concluded that non-fatal opioid overdose and attempted suicide are distinct clinically significant problems that require different approaches for prevention. Additionally, if both behaviours are reported a thorough assessment of underlying comorbid problems should be initiated by treatment services.
本研究旨在通过对 1500 名阿片类药物依赖者的既往史进行研究,确定非致命性阿片类药物过量和自杀未遂是否为不同的行为。本研究利用了作为一项大型回顾性病例对照研究的一部分所收集的数据。非致命性阿片类药物过量比自杀未遂更为常见(58%比 32%)。总体而言,与仅自杀未遂史和非致命性阿片类药物过量史相关的因素不同。与非致命性阿片类药物过量相关的药物相关风险行为(包括高冲动性、阿片类药物注射、镇静剂依赖);与自杀未遂相关的是精神障碍史(抑郁症、焦虑障碍和边缘型人格障碍筛查阳性(BPD+)。此外,报告有这两种行为史的患者具有更严重的临床特征,包括过度用药、心理障碍和童年创伤。该研究得出结论,非致命性阿片类药物过量和自杀未遂是不同的具有临床意义的问题,需要采取不同的预防方法。此外,如果报告了这两种行为,治疗服务机构应启动对潜在共病问题的全面评估。